Interpreting challenge data from early phase malaria blood stage vaccine trials
Introduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine researc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-03-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | http://dx.doi.org/10.1080/14760584.2018.1435278 |
| _version_ | 1827813204204453888 |
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| author | Michael F. Good Louis H. Miller |
| author_facet | Michael F. Good Louis H. Miller |
| author_sort | Michael F. Good |
| collection | DOAJ |
| description | Introduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine research and quickly eliminate candidates with poor efficacy. Areas covered: The data from these studies need to be carefully examined and interpreted in light of the very different roles that antibody and cellular immunity play in protection and within the context of the distinct clinical sensitivities of volunteers living in malaria-non-endemic countries compared to those living in endemic countries. With current strategies, it is likely that vaccines with protective immunological ‘signatures’ will be missed and potentially good candidates discarded. Expert commentary: Efficacy data from early phase vaccine trials in non-endemic countries should not be used to decide whether or not to proceed to vaccine trials in endemic countries. |
| first_indexed | 2024-03-11T23:29:26Z |
| format | Article |
| id | doaj.art-0e19cf177682415993fbc6f32d540579 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:26Z |
| publishDate | 2018-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-0e19cf177682415993fbc6f32d5405792023-09-20T10:18:03ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952018-03-0117318919610.1080/14760584.2018.14352781435278Interpreting challenge data from early phase malaria blood stage vaccine trialsMichael F. Good0Louis H. Miller1Griffith UniversityNational Institutes of HealthIntroduction: As the quest for an effective blood stage malaria vaccine continues, there is increasing reliance on the use of controlled human malaria infections (CHMI) in non-endemic settings to test vaccine efficacy at the earliest possible time. This is seen as a way to accelerate vaccine research and quickly eliminate candidates with poor efficacy. Areas covered: The data from these studies need to be carefully examined and interpreted in light of the very different roles that antibody and cellular immunity play in protection and within the context of the distinct clinical sensitivities of volunteers living in malaria-non-endemic countries compared to those living in endemic countries. With current strategies, it is likely that vaccines with protective immunological ‘signatures’ will be missed and potentially good candidates discarded. Expert commentary: Efficacy data from early phase vaccine trials in non-endemic countries should not be used to decide whether or not to proceed to vaccine trials in endemic countries.http://dx.doi.org/10.1080/14760584.2018.1435278malaria vaccinessub-unit vaccineswhole parasite vaccinescellular immunityantibody-mediated immunitychmi |
| spellingShingle | Michael F. Good Louis H. Miller Interpreting challenge data from early phase malaria blood stage vaccine trials Expert Review of Vaccines malaria vaccines sub-unit vaccines whole parasite vaccines cellular immunity antibody-mediated immunity chmi |
| title | Interpreting challenge data from early phase malaria blood stage vaccine trials |
| title_full | Interpreting challenge data from early phase malaria blood stage vaccine trials |
| title_fullStr | Interpreting challenge data from early phase malaria blood stage vaccine trials |
| title_full_unstemmed | Interpreting challenge data from early phase malaria blood stage vaccine trials |
| title_short | Interpreting challenge data from early phase malaria blood stage vaccine trials |
| title_sort | interpreting challenge data from early phase malaria blood stage vaccine trials |
| topic | malaria vaccines sub-unit vaccines whole parasite vaccines cellular immunity antibody-mediated immunity chmi |
| url | http://dx.doi.org/10.1080/14760584.2018.1435278 |
| work_keys_str_mv | AT michaelfgood interpretingchallengedatafromearlyphasemalariabloodstagevaccinetrials AT louishmiller interpretingchallengedatafromearlyphasemalariabloodstagevaccinetrials |