Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution
Abstract A novel glass‐ceramic strategy for synthesizing mixed phase diopside (CaMgSi2O6)–lithium oxide (Li2O) bioceramics with excellent mechanical strength, superior biodegradation resistance, low environmental pH impact, enhanced bioactivity, and reasonable biocompatibility is developed for biome...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-04-01
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| Series: | Advanced Materials Interfaces |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/admi.202202491 |
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| author | Yu‐Sheng Tseng Yun‐Han Su Chia‐Lin Chen Ji Zhang Chih‐Kuang Wang Dorian Amir Henry Hanaor Wen‐Fan Chen |
| author_facet | Yu‐Sheng Tseng Yun‐Han Su Chia‐Lin Chen Ji Zhang Chih‐Kuang Wang Dorian Amir Henry Hanaor Wen‐Fan Chen |
| author_sort | Yu‐Sheng Tseng |
| collection | DOAJ |
| description | Abstract A novel glass‐ceramic strategy for synthesizing mixed phase diopside (CaMgSi2O6)–lithium oxide (Li2O) bioceramics with excellent mechanical strength, superior biodegradation resistance, low environmental pH impact, enhanced bioactivity, and reasonable biocompatibility is developed for biomedical applications. The substitution of Li2O for MgO in CaMgSi2O6 stimulates the formation of secondary phases: CaSiO3, Li2Si2O5, SiO2, Li2SiO3, and Li2Ca2Si5O13. The evolution of CaSiO3 improves the surface hydroxyapatite (HAp) formation but lowers the mechanical strength and biological resistance, while the amorphous Li2Si2O5 phase tremendously reinforces the bioceramics by densifying the microstructure, indicating the simultaneous enhancement of bioactivity, mechanical strength, and durability. The promoted HAp formation is induced by the elemental redistribution where Mg elements are concentrated in large CaMgSi2O6 grains embedded in Li2Si2O5 amorphous matrix, which hinders the Mg2+ release and its readsorption by HAp. The cell viability is affected by Li2O substitution because of the high‐dose Li+. In the current work, Li0.25 (25 mol% Li2O) has the highest hardness (700 Hv as sintered and 197 Hv after simulated body fluid soaking), lowest weight loss (≈0.6 wt%), lowest pH variation (≈8.1), efficient HAp formation, and reasonable cell viability (70.5%), demonstrating its remarkable potential for bone implant applications due to the synergistic structural densification and biological improvement. |
| first_indexed | 2024-03-12T21:51:49Z |
| format | Article |
| id | doaj.art-0e1dc1d6675e486f815a44d7c3b9d2c2 |
| institution | Directory Open Access Journal |
| issn | 2196-7350 |
| language | English |
| last_indexed | 2024-03-12T21:51:49Z |
| publishDate | 2023-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj.art-0e1dc1d6675e486f815a44d7c3b9d2c22023-07-26T01:35:54ZengWiley-VCHAdvanced Materials Interfaces2196-73502023-04-011012n/an/a10.1002/admi.202202491Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental RedistributionYu‐Sheng Tseng0Yun‐Han Su1Chia‐Lin Chen2Ji Zhang3Chih‐Kuang Wang4Dorian Amir Henry Hanaor5Wen‐Fan Chen6Institute of Medical Science and Technology National Sun Yat‐Sen University Kaohsiung 80424 TaiwanInstitute of Medical Science and Technology National Sun Yat‐Sen University Kaohsiung 80424 TaiwanInstitute of Medical Science and Technology National Sun Yat‐Sen University Kaohsiung 80424 TaiwanSchool of Materials Science and Engineering UNSW Sydney Sydney NSW 2052 AustraliaDepartment of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 80708 TaiwanSchool of Materials Science and Engineering UNSW Sydney Sydney NSW 2052 AustraliaInstitute of Medical Science and Technology National Sun Yat‐Sen University Kaohsiung 80424 TaiwanAbstract A novel glass‐ceramic strategy for synthesizing mixed phase diopside (CaMgSi2O6)–lithium oxide (Li2O) bioceramics with excellent mechanical strength, superior biodegradation resistance, low environmental pH impact, enhanced bioactivity, and reasonable biocompatibility is developed for biomedical applications. The substitution of Li2O for MgO in CaMgSi2O6 stimulates the formation of secondary phases: CaSiO3, Li2Si2O5, SiO2, Li2SiO3, and Li2Ca2Si5O13. The evolution of CaSiO3 improves the surface hydroxyapatite (HAp) formation but lowers the mechanical strength and biological resistance, while the amorphous Li2Si2O5 phase tremendously reinforces the bioceramics by densifying the microstructure, indicating the simultaneous enhancement of bioactivity, mechanical strength, and durability. The promoted HAp formation is induced by the elemental redistribution where Mg elements are concentrated in large CaMgSi2O6 grains embedded in Li2Si2O5 amorphous matrix, which hinders the Mg2+ release and its readsorption by HAp. The cell viability is affected by Li2O substitution because of the high‐dose Li+. In the current work, Li0.25 (25 mol% Li2O) has the highest hardness (700 Hv as sintered and 197 Hv after simulated body fluid soaking), lowest weight loss (≈0.6 wt%), lowest pH variation (≈8.1), efficient HAp formation, and reasonable cell viability (70.5%), demonstrating its remarkable potential for bone implant applications due to the synergistic structural densification and biological improvement.https://doi.org/10.1002/admi.202202491bioactivitiesdiopsidelithium oxidesmechanical properties |
| spellingShingle | Yu‐Sheng Tseng Yun‐Han Su Chia‐Lin Chen Ji Zhang Chih‐Kuang Wang Dorian Amir Henry Hanaor Wen‐Fan Chen Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution Advanced Materials Interfaces bioactivities diopside lithium oxides mechanical properties |
| title | Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution |
| title_full | Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution |
| title_fullStr | Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution |
| title_full_unstemmed | Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution |
| title_short | Bioceramics in the CaMgSi2O6–Li2O System: A Glass‐Ceramic Strategy for Excellent Mechanical Strength and Enhanced Bioactivity by Spontaneous Elemental Redistribution |
| title_sort | bioceramics in the camgsi2o6 li2o system a glass ceramic strategy for excellent mechanical strength and enhanced bioactivity by spontaneous elemental redistribution |
| topic | bioactivities diopside lithium oxides mechanical properties |
| url | https://doi.org/10.1002/admi.202202491 |
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