Activity of kallikrein-kinin system at patients with asiderotic anemia
The aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after 3 weeks have been examined. KKS state has bee...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2004-06-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3629 |
| _version_ | 1827992051476594688 |
|---|---|
| author | N. N. Zhilkova |
| author_facet | N. N. Zhilkova |
| author_sort | N. N. Zhilkova |
| collection | DOAJ |
| description | The aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after 3 weeks have been examined. KKS state has been estimated by kallikrein, prekallikrein, proteinase α1-inhibitor (Pα1I) and α2-macroglobulin (α2-MG) levels in blood plasma having been investigated by Paskhina’s et al.chromatographic method and by Nartikova’s and Paskhina’s unified enzymatic method.Patients with asiderotic anemia had the rise of KKS activity. Its change differences depending on the disease duration have been revealed. At short disease duration a regulated KKS activation and its stable state have been marked. After the treatment at patients with medium severity degree it happens a normalization of all KKS parameters, at patients with serious anemia the high activity of Pα1I persists. The continuous treatment of anemia has led to the development of pathological type activation that had persisted at patients after the treatment.It has been revealed that the degree of KKS activation intensity and its renewal after the implemented treatment depended on the duration and severity of the disease. |
| first_indexed | 2024-04-10T01:14:51Z |
| format | Article |
| id | doaj.art-0e1eed9c48c24067a2c465a48e31a932 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:14:51Z |
| publishDate | 2004-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-0e1eed9c48c24067a2c465a48e31a9322023-03-13T09:58:02ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842004-06-0132566110.20538/1682-0363-2004-2-56-612271Activity of kallikrein-kinin system at patients with asiderotic anemiaN. N. Zhilkova0Владивостокский государственный медицинский университетThe aim of investigation is to study the state of kallikrein-kinin system (KKS) and proteinase inhibitors at patients with asiderotic anemia prior to and after the treatment. 58 patients with asiderotic anemia prior to the treatment and in dynamics after 3 weeks have been examined. KKS state has been estimated by kallikrein, prekallikrein, proteinase α1-inhibitor (Pα1I) and α2-macroglobulin (α2-MG) levels in blood plasma having been investigated by Paskhina’s et al.chromatographic method and by Nartikova’s and Paskhina’s unified enzymatic method.Patients with asiderotic anemia had the rise of KKS activity. Its change differences depending on the disease duration have been revealed. At short disease duration a regulated KKS activation and its stable state have been marked. After the treatment at patients with medium severity degree it happens a normalization of all KKS parameters, at patients with serious anemia the high activity of Pα1I persists. The continuous treatment of anemia has led to the development of pathological type activation that had persisted at patients after the treatment.It has been revealed that the degree of KKS activation intensity and its renewal after the implemented treatment depended on the duration and severity of the disease.https://bulletin.ssmu.ru/jour/article/view/3629калликреинпрекалликреинα<sub>1</sub>-ингибитор протеиназα<sub>2</sub>-макроглобулинжелезодефицитная анемияплазма крови |
| spellingShingle | N. N. Zhilkova Activity of kallikrein-kinin system at patients with asiderotic anemia Бюллетень сибирской медицины калликреин прекалликреин α<sub>1</sub>-ингибитор протеиназ α<sub>2</sub>-макроглобулин железодефицитная анемия плазма крови |
| title | Activity of kallikrein-kinin system at patients with asiderotic anemia |
| title_full | Activity of kallikrein-kinin system at patients with asiderotic anemia |
| title_fullStr | Activity of kallikrein-kinin system at patients with asiderotic anemia |
| title_full_unstemmed | Activity of kallikrein-kinin system at patients with asiderotic anemia |
| title_short | Activity of kallikrein-kinin system at patients with asiderotic anemia |
| title_sort | activity of kallikrein kinin system at patients with asiderotic anemia |
| topic | калликреин прекалликреин α<sub>1</sub>-ингибитор протеиназ α<sub>2</sub>-макроглобулин железодефицитная анемия плазма крови |
| url | https://bulletin.ssmu.ru/jour/article/view/3629 |
| work_keys_str_mv | AT nnzhilkova activityofkallikreinkininsystematpatientswithasideroticanemia |