MARTX Toxin in the Zoonotic Serovar of Vibrio vulnificus Triggers an Early Cytokine Storm in Mice

MARTX Toxin in the Zoonotic Serovar of Vibrio vulnificus Triggers an Early Cytokine Storm in Mice

Vibrio vulnificus biotype 2-serovar E is a zoonotic clonal complex that can cause death by sepsis in humans and fish. Unlike other biotypes, Bt2 produces a unique type of MARTXVv (Multifunctional-Autoprocessive-Repeats-in-Toxin; RtxA13), which is encoded by a gene duplicated in the pVvBt2 plasmid an...

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Bibliographic Details
Main Authors: Celia Murciano, Chung-Te Lee, Ana Fernández-Bravo, Tsung-Han Hsieh, Belén Fouz, Lien-I Hor, Carmen Amaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Vibrio
V. vulnificus
MARTX
sepsis
infection
gene expression
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00332/full

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