Role of Neddylation in Neurodegenerative Diseases
Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | NeuroSci |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4087/3/4/38 |
| _version_ | 1797455906514927616 |
|---|---|
| author | Manoj Govindarajulu Sindhu Ramesh Tharanth Shankar Murali Krishna Kora Timothy Moore Muralikrishnan Dhanasekaran |
| author_facet | Manoj Govindarajulu Sindhu Ramesh Tharanth Shankar Murali Krishna Kora Timothy Moore Muralikrishnan Dhanasekaran |
| author_sort | Manoj Govindarajulu |
| collection | DOAJ |
| description | Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases. |
| first_indexed | 2024-03-09T16:00:56Z |
| format | Article |
| id | doaj.art-0e215285fa8c451d9551a9a09333f97b |
| institution | Directory Open Access Journal |
| issn | 2673-4087 |
| language | English |
| last_indexed | 2024-03-09T16:00:56Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | NeuroSci |
| spelling | doaj.art-0e215285fa8c451d9551a9a09333f97b2023-11-24T17:06:16ZengMDPI AGNeuroSci2673-40872022-09-013453354510.3390/neurosci3040038Role of Neddylation in Neurodegenerative DiseasesManoj Govindarajulu0Sindhu Ramesh1Tharanth Shankar2Murali Krishna Kora3Timothy Moore4Muralikrishnan Dhanasekaran5Department of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USADepartment of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USADepartment of Internal Medicine, Ramaiah Medical College and Hospital, Bengaluru 560054, Karnataka, IndiaSveta Clinic, Bengaluru 560038, Karnataka, IndiaDepartment of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USADepartment of Drug Discovery and Development, Auburn University Harrison School of Pharmacy, Auburn, AL 36849, USANeurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases.https://www.mdpi.com/2673-4087/3/4/38neddylationAlzheimer’s diseaseParkinson’s diseaseneurodegenerative diseasesNEDD8misfolded proteins |
| spellingShingle | Manoj Govindarajulu Sindhu Ramesh Tharanth Shankar Murali Krishna Kora Timothy Moore Muralikrishnan Dhanasekaran Role of Neddylation in Neurodegenerative Diseases NeuroSci neddylation Alzheimer’s disease Parkinson’s disease neurodegenerative diseases NEDD8 misfolded proteins |
| title | Role of Neddylation in Neurodegenerative Diseases |
| title_full | Role of Neddylation in Neurodegenerative Diseases |
| title_fullStr | Role of Neddylation in Neurodegenerative Diseases |
| title_full_unstemmed | Role of Neddylation in Neurodegenerative Diseases |
| title_short | Role of Neddylation in Neurodegenerative Diseases |
| title_sort | role of neddylation in neurodegenerative diseases |
| topic | neddylation Alzheimer’s disease Parkinson’s disease neurodegenerative diseases NEDD8 misfolded proteins |
| url | https://www.mdpi.com/2673-4087/3/4/38 |
| work_keys_str_mv | AT manojgovindarajulu roleofneddylationinneurodegenerativediseases AT sindhuramesh roleofneddylationinneurodegenerativediseases AT tharanthshankar roleofneddylationinneurodegenerativediseases AT muralikrishnakora roleofneddylationinneurodegenerativediseases AT timothymoore roleofneddylationinneurodegenerativediseases AT muralikrishnandhanasekaran roleofneddylationinneurodegenerativediseases |