mRNA Sonotransfection of Tumors with Polymeric Microbubbles: Co‐Formulation versus Co‐Administration

mRNA Sonotransfection of Tumors with Polymeric Microbubbles: Co‐Formulation versus Co‐Administration

Abstract Despite its high potential, non‐viral gene therapy of cancer remains challenging due to inefficient nucleic acid delivery. Ultrasound (US) with microbubbles (MB) can open biological barriers and thus improve DNA and mRNA passage. Polymeric MB are an interesting alternative to clinically use...

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Bibliographic Details
Main Authors: Junlin Chen, Bi Wang, Yuchen Wang, Harald Radermacher, Jinwei Qi, Jeffrey Momoh, Twan Lammers, Yang Shi, Anne Rix, Fabian Kiessling
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
co‐administration
co‐formulation
focused ultrasound
lipoplexes
mRNA delivery
PBCA microbubbles
Online Access:https://doi.org/10.1002/advs.202306139

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