Response of Sport Horses to Different Formulations of Equine Influenza Vaccine
The international governing body of equestrian sports requires that horses be vaccinated against equine influenza within 6 months and 21 days of competing. The aim of this study was to compare the antibody response of young sport horses to six-monthly booster vaccination with equine influenza vaccin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/3/372 |
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| author | Johanna Entenfellner Jacinta Gahan Marie Garvey Cathal Walsh Monica Venner Ann Cullinane |
| author_facet | Johanna Entenfellner Jacinta Gahan Marie Garvey Cathal Walsh Monica Venner Ann Cullinane |
| author_sort | Johanna Entenfellner |
| collection | DOAJ |
| description | The international governing body of equestrian sports requires that horses be vaccinated against equine influenza within 6 months and 21 days of competing. The aim of this study was to compare the antibody response of young sport horses to six-monthly booster vaccination with equine influenza vaccines of different formulations. An inactivated vaccine was allocated to 35 horses and subunit and recombinant vaccines were allocated to 34 horses each. After vaccination, all horses were monitored for evidence of adverse reactions. Whole blood samples were collected at the time of vaccination and on nine occasions up to six months and 21 days post vaccination. Antibodies against equine influenza were measured by single radial haemolysis. Transient fever and injection site reactions were observed in several horses vaccinated with each vaccine. Only two horses failed to seroconvert post booster vaccination but there was a delayed response to the recombinant vaccine. The antibody response to the recombinant vaccine was lower than that induced by the whole-inactivated and subunit vaccines up to three months post vaccination. Thereafter, there was no significant difference. By six months post vaccination, the majority of horses in all three groups were clinically but not virologically protected. There was minimal decline in antibody titres within the 21-day grace period. |
| first_indexed | 2024-03-10T18:33:11Z |
| format | Article |
| id | doaj.art-0e23465f9817488bb430f2cb21e92cb9 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T18:33:11Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-0e23465f9817488bb430f2cb21e92cb92023-11-20T06:27:29ZengMDPI AGVaccines2076-393X2020-07-018337210.3390/vaccines8030372Response of Sport Horses to Different Formulations of Equine Influenza VaccineJohanna Entenfellner0Jacinta Gahan1Marie Garvey2Cathal Walsh3Monica Venner4Ann Cullinane5School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, GermanyIrish Equine Centre, Johnstown, Naas, Co. Kildare, W91 RH93 Johnstown, IrelandIrish Equine Centre, Johnstown, Naas, Co. Kildare, W91 RH93 Johnstown, IrelandDepartment of Mathematics and Statistics, University of Limerick, V94 T9PX Limerick, IrelandPferdeklinik Destedt GmbH, Destedt, Trift 4, 38162 Cremlingen, GermanyIrish Equine Centre, Johnstown, Naas, Co. Kildare, W91 RH93 Johnstown, IrelandThe international governing body of equestrian sports requires that horses be vaccinated against equine influenza within 6 months and 21 days of competing. The aim of this study was to compare the antibody response of young sport horses to six-monthly booster vaccination with equine influenza vaccines of different formulations. An inactivated vaccine was allocated to 35 horses and subunit and recombinant vaccines were allocated to 34 horses each. After vaccination, all horses were monitored for evidence of adverse reactions. Whole blood samples were collected at the time of vaccination and on nine occasions up to six months and 21 days post vaccination. Antibodies against equine influenza were measured by single radial haemolysis. Transient fever and injection site reactions were observed in several horses vaccinated with each vaccine. Only two horses failed to seroconvert post booster vaccination but there was a delayed response to the recombinant vaccine. The antibody response to the recombinant vaccine was lower than that induced by the whole-inactivated and subunit vaccines up to three months post vaccination. Thereafter, there was no significant difference. By six months post vaccination, the majority of horses in all three groups were clinically but not virologically protected. There was minimal decline in antibody titres within the 21-day grace period.https://www.mdpi.com/2076-393X/8/3/372equine influenzainactivatedsubunitrecombinant vaccinessport horseantibody |
| spellingShingle | Johanna Entenfellner Jacinta Gahan Marie Garvey Cathal Walsh Monica Venner Ann Cullinane Response of Sport Horses to Different Formulations of Equine Influenza Vaccine Vaccines equine influenza inactivated subunit recombinant vaccines sport horse antibody |
| title | Response of Sport Horses to Different Formulations of Equine Influenza Vaccine |
| title_full | Response of Sport Horses to Different Formulations of Equine Influenza Vaccine |
| title_fullStr | Response of Sport Horses to Different Formulations of Equine Influenza Vaccine |
| title_full_unstemmed | Response of Sport Horses to Different Formulations of Equine Influenza Vaccine |
| title_short | Response of Sport Horses to Different Formulations of Equine Influenza Vaccine |
| title_sort | response of sport horses to different formulations of equine influenza vaccine |
| topic | equine influenza inactivated subunit recombinant vaccines sport horse antibody |
| url | https://www.mdpi.com/2076-393X/8/3/372 |
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