Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

Abstract Background Excessive iron contributes to oxidative stress after central nervous system injury. NADPH oxidase (NOX) enzymes are upregulated in microglia after pro-inflammatory activation and contribute to oxidative stress. The relationship between iron, microglia, NOX, and oxidative stress i...

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Bibliographic Details
Main Authors: Young J. Yauger, Sara Bermudez, Kasey E. Moritz, Ethan Glaser, Bogdan Stoica, Kimberly R. Byrnes
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Neuroinflammation
Subjects:
BV2
Iron sulfate
Neuronal toxicity
Microglial polarization
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-019-1430-7

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