Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial
Abstract Background Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-019-0952-x |
| _version_ | 1818291111465058304 |
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| author | Owen Cronin Wiley Barton Carthage Moran Donal Sheehan Ronan Whiston Helena Nugent Yvonne McCarthy Catherine B. Molloy Orla O’Sullivan Paul D. Cotter Michael G. Molloy Fergus Shanahan |
| author_facet | Owen Cronin Wiley Barton Carthage Moran Donal Sheehan Ronan Whiston Helena Nugent Yvonne McCarthy Catherine B. Molloy Orla O’Sullivan Paul D. Cotter Michael G. Molloy Fergus Shanahan |
| author_sort | Owen Cronin |
| collection | DOAJ |
| description | Abstract Background Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 ± 6.5 years and Body Mass Index of 28.9 ± 3.8 were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. Results Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the α- and β-diversity of gut microbiota and associated metabolic pathways were evident. Conclusions Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects. Trial registration The study was registered at ClinicalTrials.gov; Trial number: NCT02463916. |
| first_indexed | 2024-12-13T02:38:52Z |
| format | Article |
| id | doaj.art-0e2af7649ba8478e820d13859ed58207 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-13T02:38:52Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-0e2af7649ba8478e820d13859ed582072022-12-22T00:02:20ZengBMCBMC Gastroenterology1471-230X2019-02-0119111110.1186/s12876-019-0952-xModerate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trialOwen Cronin0Wiley Barton1Carthage Moran2Donal Sheehan3Ronan Whiston4Helena Nugent5Yvonne McCarthy6Catherine B. Molloy7Orla O’Sullivan8Paul D. Cotter9Michael G. Molloy10Fergus Shanahan11Department of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalTeagasc Food Research CentreDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalAPC Microbiome Ireland, National University of IrelandAPC Microbiome Ireland, National University of IrelandDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalDepartment of Medicine, National University of Ireland, University College Cork, Cork University HospitalAbstract Background Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease. Methods A randomized, cross-over trial of eight weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age of 25 ± 6.5 years and Body Mass Index of 28.9 ± 3.8 were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota assessed using metagenomic sequencing. Results Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p = 0.03). Improvement in body composition was achieved by the intervention group (n = 13) with a median decrease of 2.1% body fat compared with a non-exercising group (n = 7) (0.1% increase; p = 0.022). Lean tissue mass increased by a median of 1.59 kg and fat mass decreased by a median of 1.52 kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. No clinically significant alterations in the α- and β-diversity of gut microbiota and associated metabolic pathways were evident. Conclusions Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects. Trial registration The study was registered at ClinicalTrials.gov; Trial number: NCT02463916.http://link.springer.com/article/10.1186/s12876-019-0952-xClinical trialsMicrobiomeExerciseBody composition |
| spellingShingle | Owen Cronin Wiley Barton Carthage Moran Donal Sheehan Ronan Whiston Helena Nugent Yvonne McCarthy Catherine B. Molloy Orla O’Sullivan Paul D. Cotter Michael G. Molloy Fergus Shanahan Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial BMC Gastroenterology Clinical trials Microbiome Exercise Body composition |
| title | Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial |
| title_full | Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial |
| title_fullStr | Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial |
| title_full_unstemmed | Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial |
| title_short | Moderate-intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent Inflammatory Bowel Disease: a randomized controlled cross-over trial |
| title_sort | moderate intensity aerobic and resistance exercise is safe and favorably influences body composition in patients with quiescent inflammatory bowel disease a randomized controlled cross over trial |
| topic | Clinical trials Microbiome Exercise Body composition |
| url | http://link.springer.com/article/10.1186/s12876-019-0952-x |
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