Response of the cardiovascular system of cats to ansamycins in the test for depressor substances
The article summarises the results of a study which assessed the response of the cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections. It was shown that intrav...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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NEICON ISP LLC
2018-02-01
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| Series: | Ведомости Научного центра экспертизы средств медицинского применения |
| Subjects: | |
| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/112 |
| _version_ | 1797199034298925056 |
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| author | L. V. Simutenko T. A. Batuashvili N. P. Neugodova E. O. Stepanyuk S. I. Kuleshova |
| author_facet | L. V. Simutenko T. A. Batuashvili N. P. Neugodova E. O. Stepanyuk S. I. Kuleshova |
| author_sort | L. V. Simutenko |
| collection | DOAJ |
| description | The article summarises the results of a study which assessed the response of the cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections. It was shown that intravenous administration of ansamycin solutions was accompanied by hypotensive effects of varying severity. The increase in the rate of rifampicin administration at a dose of 2.0 mg/0.5 ml/kg can result in a greater decrease of the cat’s blood pressure as compared to the effect caused by the administration of the same dose at a rate described in the monograph 1.2.4.0008.15 «Test for depressor substances». Based on the results of the study a mechanism underlying the observed effect was suggested. |
| first_indexed | 2024-03-07T19:17:44Z |
| format | Article |
| id | doaj.art-0e2b7fda005f43bda65b8754a570bff1 |
| institution | Directory Open Access Journal |
| issn | 1991-2919 2619-1172 |
| language | Russian |
| last_indexed | 2024-04-24T07:09:20Z |
| publishDate | 2018-02-01 |
| publisher | NEICON ISP LLC |
| record_format | Article |
| series | Ведомости Научного центра экспертизы средств медицинского применения |
| spelling | doaj.art-0e2b7fda005f43bda65b8754a570bff12024-04-21T11:46:32ZrusNEICON ISP LLCВедомости Научного центра экспертизы средств медицинского применения1991-29192619-11722018-02-01711519110Response of the cardiovascular system of cats to ansamycins in the test for depressor substancesL. V. Simutenko0T. A. Batuashvili1N. P. Neugodova2E. O. Stepanyuk3S. I. Kuleshova4Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsThe article summarises the results of a study which assessed the response of the cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections. It was shown that intravenous administration of ansamycin solutions was accompanied by hypotensive effects of varying severity. The increase in the rate of rifampicin administration at a dose of 2.0 mg/0.5 ml/kg can result in a greater decrease of the cat’s blood pressure as compared to the effect caused by the administration of the same dose at a rate described in the monograph 1.2.4.0008.15 «Test for depressor substances». Based on the results of the study a mechanism underlying the observed effect was suggested.https://www.vedomostincesmp.ru/jour/article/view/112рифампицинрифабутиндепрессорные веществагистаминсердечно-сосудистая системаартериальное давлениеrifampicinrifabutindepressor substanceshistaminecardiovascular systemblood pressure |
| spellingShingle | L. V. Simutenko T. A. Batuashvili N. P. Neugodova E. O. Stepanyuk S. I. Kuleshova Response of the cardiovascular system of cats to ansamycins in the test for depressor substances Ведомости Научного центра экспертизы средств медицинского применения рифампицин рифабутин депрессорные вещества гистамин сердечно-сосудистая система артериальное давление rifampicin rifabutin depressor substances histamine cardiovascular system blood pressure |
| title | Response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| title_full | Response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| title_fullStr | Response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| title_full_unstemmed | Response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| title_short | Response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| title_sort | response of the cardiovascular system of cats to ansamycins in the test for depressor substances |
| topic | рифампицин рифабутин депрессорные вещества гистамин сердечно-сосудистая система артериальное давление rifampicin rifabutin depressor substances histamine cardiovascular system blood pressure |
| url | https://www.vedomostincesmp.ru/jour/article/view/112 |
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