Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance
Antimicrobial resistance in pathogenic <i>Neisseria</i> parallels reduced antimicrobial susceptibility in commensal <i>Neisseria</i> in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobi...
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| Format: | Artykuł |
| Język: | English |
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MDPI AG
2020-03-01
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| Seria: | Pathogens |
| Hasła przedmiotowe: | |
| Dostęp online: | https://www.mdpi.com/2076-0817/9/3/228 |
| _version_ | 1828349713391288320 |
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| author | Christophe Van Dijck Jolein G. E. Laumen Sheeba S. Manoharan-Basil Chris Kenyon |
| author_facet | Christophe Van Dijck Jolein G. E. Laumen Sheeba S. Manoharan-Basil Chris Kenyon |
| author_sort | Christophe Van Dijck |
| collection | DOAJ |
| description | Antimicrobial resistance in pathogenic <i>Neisseria</i> parallels reduced antimicrobial susceptibility in commensal <i>Neisseria</i> in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal <i>Neisseria</i> are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral <i>Neisseria</i> communities of intimate partners were more similar than those of unrelated individuals (average Morisita−Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (<i>p</i> = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (<i>p</i> = 0.006)). This similarity presumably results from transmission of oral <i>Neisseria</i> through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in <i>Neisseria</i>. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence. |
| first_indexed | 2024-04-14T01:13:46Z |
| format | Article |
| id | doaj.art-0e2bfe2f5c1d41eb8e1aa03022e00f08 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-14T01:13:46Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-0e2bfe2f5c1d41eb8e1aa03022e00f082022-12-22T02:20:56ZengMDPI AGPathogens2076-08172020-03-019322810.3390/pathogens9030228pathogens9030228Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial ResistanceChristophe Van Dijck0Jolein G. E. Laumen1Sheeba S. Manoharan-Basil2Chris Kenyon3Department of Clinical Sciences, Institute of Tropical Medicine Antwerp, 2000 Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, 2000 Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, 2000 Antwerp, BelgiumDepartment of Clinical Sciences, Institute of Tropical Medicine Antwerp, 2000 Antwerp, BelgiumAntimicrobial resistance in pathogenic <i>Neisseria</i> parallels reduced antimicrobial susceptibility in commensal <i>Neisseria</i> in certain populations, like men who have sex with men (MSM). Although this reduced susceptibility can be a consequence of frequent antimicrobial exposure at the individual level, we hypothesized that commensal <i>Neisseria</i> are transmitted between sexual partners. We used data from a 2014 microbiome study in which saliva and tongue swabs were taken from 21 couples (42 individuals). Samples were analyzed using 16S rRNA gene sequencing. We compared intimate partners with unrelated individuals and found that the oral <i>Neisseria</i> communities of intimate partners were more similar than those of unrelated individuals (average Morisita−Horn dissimilarity index for saliva samples: 0.54 versus 0.71, respectively (<i>p</i> = 0.005); and for tongue swabs: 0.42 versus 0.63, respectively (<i>p</i> = 0.006)). This similarity presumably results from transmission of oral <i>Neisseria</i> through intimate kissing. This finding suggests that intensive gonorrhea screening in MSM may, via increased antimicrobial exposure, promote, rather than prevent, the emergence and spread of antimicrobial resistance in <i>Neisseria</i>. Non-antibiotic strategies such as vaccines and oral antiseptics could prove more sustainable options to reduce gonococcal prevalence.https://www.mdpi.com/2076-0817/9/3/228commensal<i>neisseria</i>gonorrhea<i>meningitidis</i>kissingsharingmicrobiometransmissionantimicrobial resistance |
| spellingShingle | Christophe Van Dijck Jolein G. E. Laumen Sheeba S. Manoharan-Basil Chris Kenyon Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance Pathogens commensal <i>neisseria</i> gonorrhea <i>meningitidis</i> kissing sharing microbiome transmission antimicrobial resistance |
| title | Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
| title_full | Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
| title_fullStr | Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
| title_full_unstemmed | Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
| title_short | Commensal <i>Neisseria</i> Are Shared between Sexual Partners: Implications for Gonococcal and Meningococcal Antimicrobial Resistance |
| title_sort | commensal i neisseria i are shared between sexual partners implications for gonococcal and meningococcal antimicrobial resistance |
| topic | commensal <i>neisseria</i> gonorrhea <i>meningitidis</i> kissing sharing microbiome transmission antimicrobial resistance |
| url | https://www.mdpi.com/2076-0817/9/3/228 |
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