Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study
Background/Aim. Thyroid nodules represent a common problem in medicine. Ultrasound examination of the thyroid glands is a common method for the initial diagnosis of thyroid neoplasia enabling the selection of nodules that should undergo fine needle aspiration biopsy (FNAB). It is a noninvasive metho...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Military Health Department, Ministry of Defance, Serbia
2021-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900109K.pdf |
| _version_ | 1818462030787510272 |
|---|---|
| author | Kiković Saša Marinković Dejan M. Ristić Petar Karajović Jelena Kuzmić-Janković Snežana Đuran Zorana Čizmić Milica Kovačević Božidar Nenezić Nemanja Hajduković Zoran |
| author_facet | Kiković Saša Marinković Dejan M. Ristić Petar Karajović Jelena Kuzmić-Janković Snežana Đuran Zorana Čizmić Milica Kovačević Božidar Nenezić Nemanja Hajduković Zoran |
| author_sort | Kiković Saša |
| collection | DOAJ |
| description | Background/Aim. Thyroid nodules represent a common problem in medicine. Ultrasound examination of the thyroid glands is a common method for the initial diagnosis of thyroid neoplasia enabling the selection of nodules that should undergo fine needle aspiration biopsy (FNAB). It is a noninvasive method that has a great potential in discovering suspicious lesions, enabling timely actions for further diagnostics and potential treatment. However, it is still not clear enough how the quantitative data collected from Ultrasound elastography correlate with those obtained by other diagnostic tools used for detecting thyroid nodules. The aim of this study was to estimate the importance of ultrasound elastography in diagnostics of differentiated thyroid carcinomas but also to estimate the importance of other diagnostic procedures as well. Methods. The research was performed on patients initially referred to the Clinic of Endocrinology in Military Medical Academy, Belgrade to evaluate the status of thyroid nodules. The da-ta from ultrasound elastography was then correlated with those from other diagnostic procedures including clinical examination, echosonography, cytological and histopathological analyses. Results. Statistically significant difference between the group of patients with follicular adenoma and the group of patients with differentiated thyroid carcinoma was detected for consistency, nodules immovability, thyroglobulin (Tg) levels, presence of calcifications in the nodules and the elastographic score. Fixed nodules and those with firmer consistency were significantly more common in the group of patients with malignant lesions, in which Tg levels were higher. The elastography score 3-4 showed a high predictive value for the detection of thyroid carcinoma, unlike the elasticity score. Conclusion. Ultrasound elastography represents a new non-invasive method that has a very significant, high predictive value for the detection of thyroid carcinoma, especially in correlation with other diagnostic procedures. |
| first_indexed | 2024-12-14T23:55:34Z |
| format | Article |
| id | doaj.art-0e2c2a0a61654ff98c480112f0b7d561 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-14T23:55:34Z |
| publishDate | 2021-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-0e2c2a0a61654ff98c480112f0b7d5612022-12-21T22:43:08ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202021-01-0178658959810.2298/VSP190704109K0042-84501900109KRole and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective studyKiković Saša0Marinković Dejan M.1Ristić Petar2Karajović Jelena3Kuzmić-Janković Snežana4Đuran Zorana5Čizmić Milica6Kovačević Božidar7Nenezić Nemanja8Hajduković Zoran9Military Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Endocrinology, Belgrade, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaMilitary Medical Academy, Institute of Pathology, Belgrade, Serbia Academy of Educational and Medical Vocational Studies, Kruševac, SerbiaUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaBackground/Aim. Thyroid nodules represent a common problem in medicine. Ultrasound examination of the thyroid glands is a common method for the initial diagnosis of thyroid neoplasia enabling the selection of nodules that should undergo fine needle aspiration biopsy (FNAB). It is a noninvasive method that has a great potential in discovering suspicious lesions, enabling timely actions for further diagnostics and potential treatment. However, it is still not clear enough how the quantitative data collected from Ultrasound elastography correlate with those obtained by other diagnostic tools used for detecting thyroid nodules. The aim of this study was to estimate the importance of ultrasound elastography in diagnostics of differentiated thyroid carcinomas but also to estimate the importance of other diagnostic procedures as well. Methods. The research was performed on patients initially referred to the Clinic of Endocrinology in Military Medical Academy, Belgrade to evaluate the status of thyroid nodules. The da-ta from ultrasound elastography was then correlated with those from other diagnostic procedures including clinical examination, echosonography, cytological and histopathological analyses. Results. Statistically significant difference between the group of patients with follicular adenoma and the group of patients with differentiated thyroid carcinoma was detected for consistency, nodules immovability, thyroglobulin (Tg) levels, presence of calcifications in the nodules and the elastographic score. Fixed nodules and those with firmer consistency were significantly more common in the group of patients with malignant lesions, in which Tg levels were higher. The elastography score 3-4 showed a high predictive value for the detection of thyroid carcinoma, unlike the elasticity score. Conclusion. Ultrasound elastography represents a new non-invasive method that has a very significant, high predictive value for the detection of thyroid carcinoma, especially in correlation with other diagnostic procedures.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900109K.pdfthyroid diseasesultrasonographybiopsy, fine-needlediagnosisdifferential |
| spellingShingle | Kiković Saša Marinković Dejan M. Ristić Petar Karajović Jelena Kuzmić-Janković Snežana Đuran Zorana Čizmić Milica Kovačević Božidar Nenezić Nemanja Hajduković Zoran Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study Vojnosanitetski Pregled thyroid diseases ultrasonography biopsy, fine-needle diagnosis differential |
| title | Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study |
| title_full | Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study |
| title_fullStr | Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study |
| title_full_unstemmed | Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study |
| title_short | Role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical, echosonographic, biochumoral and cytological examination and correlation of these results with definitive histopathological finding: A retrospective study |
| title_sort | role and importance of elastography in the diagnosis of differentiated thyroid carcinomas regarding the clinical echosonographic biochumoral and cytological examination and correlation of these results with definitive histopathological finding a retrospective study |
| topic | thyroid diseases ultrasonography biopsy, fine-needle diagnosis differential |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900109K.pdf |
| work_keys_str_mv | AT kikovicsasa roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT marinkovicdejanm roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT risticpetar roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT karajovicjelena roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT kuzmicjankovicsnezana roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT đuranzorana roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT cizmicmilica roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT kovacevicbozidar roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT nenezicnemanja roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy AT hajdukoviczoran roleandimportanceofelastographyinthediagnosisofdifferentiatedthyroidcarcinomasregardingtheclinicalechosonographicbiochumoralandcytologicalexaminationandcorrelationoftheseresultswithdefinitivehistopathologicalfindingaretrospectivestudy |