Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

Helical jackknives control the gates of the double-pore K+ uptake system KtrAB

Ion channel gating is essential for cellular homeostasis and is tightly controlled. In some eukaryotic and most bacterial ligand-gated K+ channels, RCK domains regulate ion fluxes. Until now, a single regulatory mechanism has been proposed for all RCK-regulated channels, involving signal transductio...

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Bibliographic Details
Main Authors: Marina Diskowski, Ahmad Reza Mehdipour, Dorith Wunnicke, Deryck J Mills, Vedrana Mikusevic, Natalie Bärland, Jan Hoffmann, Nina Morgner, Heinz-Jürgen Steinhoff, Gerhard Hummer, Janet Vonck, Inga Hänelt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
ligand-gated ion channel
potassium transport
cryo-electron microscopy
pulsed EPR
MD simulations
membrane transport
Online Access:https://elifesciences.org/articles/24303

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