Absence of mutagenicity of plants used to treat gastrointestinal disorders
The Brazilian Savanna (locally called “Cerrado”) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species ha...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2013-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641301191S.pdf |
| _version_ | 1819259960983289856 |
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| author | Santos F.V. Andreo M. Nasser A.L.M. Moreira L.M. Vilegas W. Cуlus I.M.S. Varanda E.A. |
| author_facet | Santos F.V. Andreo M. Nasser A.L.M. Moreira L.M. Vilegas W. Cуlus I.M.S. Varanda E.A. |
| author_sort | Santos F.V. |
| collection | DOAJ |
| description | The Brazilian Savanna (locally called “Cerrado”) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use. |
| first_indexed | 2024-12-23T19:18:19Z |
| format | Article |
| id | doaj.art-0e2de8f1c0a54e459fd59914e132f7c6 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-23T19:18:19Z |
| publishDate | 2013-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-0e2de8f1c0a54e459fd59914e132f7c62022-12-21T17:34:14ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392013-01-0165119119510.2298/ABS1301191SAbsence of mutagenicity of plants used to treat gastrointestinal disordersSantos F.V.Andreo M.Nasser A.L.M.Moreira L.M.Vilegas W.Cуlus I.M.S.Varanda E.A.The Brazilian Savanna (locally called “Cerrado”) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with compounds obtained from different species have shown the risks of DNA damage. The present work assessed the in vivo mutagenicity of three plant species used in popular medicine to treat human gastrointestinal disorders (Mouriri pusa, Qualea grandiflora and Qualea multiflora). The micronucleus assay was performed in peripheral blood of mice submitted to acute treatments. Results showed that no assessed extracts were mutagenic in vivo. In fact, the absence of mutagenicity in the present study indicates that the extracts do not contain compounds capable of inducing DNA breaks or chromosomal loss. However, further analysis should be performed in others systems to guarantee their safety, mainly to human chronic use.http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641301191S.pdfMutagenicitymicronucleus assaymedicinal plantsBrazilian savannaDNA damage |
| spellingShingle | Santos F.V. Andreo M. Nasser A.L.M. Moreira L.M. Vilegas W. Cуlus I.M.S. Varanda E.A. Absence of mutagenicity of plants used to treat gastrointestinal disorders Archives of Biological Sciences Mutagenicity micronucleus assay medicinal plants Brazilian savanna DNA damage |
| title | Absence of mutagenicity of plants used to treat gastrointestinal disorders |
| title_full | Absence of mutagenicity of plants used to treat gastrointestinal disorders |
| title_fullStr | Absence of mutagenicity of plants used to treat gastrointestinal disorders |
| title_full_unstemmed | Absence of mutagenicity of plants used to treat gastrointestinal disorders |
| title_short | Absence of mutagenicity of plants used to treat gastrointestinal disorders |
| title_sort | absence of mutagenicity of plants used to treat gastrointestinal disorders |
| topic | Mutagenicity micronucleus assay medicinal plants Brazilian savanna DNA damage |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641301191S.pdf |
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