E3 Ubiquitin Ligase <i>Uhrf2</i> Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus

E3 Ubiquitin Ligase <i>Uhrf2</i> Knockout Reveals a Critical Role in Social Behavior and Synaptic Plasticity in the Hippocampus

The hippocampal formation, particularly the CA2 subregion, is critical for social memory formation and memory processing, relying on synaptic plasticity—a fundamental mechanism by which synapses strengthen. Given the role of the ubiquitin–proteasome system (UPS) in various nervous system processes,...

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Bibliographic Details
Main Authors: Yinghan Zhuang, Chuhan Li, Fang Zhao, Yan Yan, Hongjie Pan, Jianmin Zhan, Thomas Behnisch
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
E3 ubiquitin ligase
UHRF2
social memory
CA2
synaptic plasticity
hippocampus
Online Access:https://www.mdpi.com/1422-0067/25/3/1543

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