Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Abstract Background Melanoma is the most aggressive and deadly form of skin cancer with increasing case numbers worldwide. The development of inhibitors targeting mutated BRAF (found in around 60% of melanoma patients) has markedly improved overall survival of patients with late-stage tumors, even m...

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Bibliographic Details
Main Authors: Christiane Margue, Demetra Philippidou, Ines Kozar, Giulia Cesi, Paul Felten, Dagmar Kulms, Elisabeth Letellier, Claude Haan, Stephanie Kreis
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma
Resistance
Kinase inhibitor
Cell cycle checkpoints
DNA damage response
Online Access:http://link.springer.com/article/10.1186/s13046-019-1038-x

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