Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis
Background and purposeTransient ischemic attack (TIA) increases the risk for a subsequent stroke. Typical symptoms include motor weakness, gait disturbance, and loss of coordination. The association between the presence of motor impairments during a TIA and the chances of a subsequent stroke has not...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00243/full |
| _version_ | 1819084031043567616 |
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| author | Neha Lodha Jane Harrell Stephan Eisenschenk Evangelos A. Christou |
| author_facet | Neha Lodha Jane Harrell Stephan Eisenschenk Evangelos A. Christou |
| author_sort | Neha Lodha |
| collection | DOAJ |
| description | Background and purposeTransient ischemic attack (TIA) increases the risk for a subsequent stroke. Typical symptoms include motor weakness, gait disturbance, and loss of coordination. The association between the presence of motor impairments during a TIA and the chances of a subsequent stroke has not been examined. In the current meta-analysis, we examine whether the odds of a stroke are greater in TIA individuals who experience motor impairments as compared with those who do not experience motor impairments.MethodsWe conducted a systematic search of electronic databases as well as manual searches of the reference lists of retrieved articles. The meta-analysis included studies that reported an odds ratio relating motor impairments to a subsequent stroke, or the number of individuals with or without motor impairments who experienced a subsequent stroke. We examined these studies using rigorous meta-analysis techniques including random effects model, forest and funnel plots, I2, publication bias, and fail-safe analysis.ResultsTwenty-four studies with 15,129 participants from North America, Australia, Asia, and Europe qualified for inclusion. An odds ratio of 2.11 (95% CI, 1.67–2.65, p = 0.000) suggested that the chances of a subsequent stroke are increased by twofolds in individuals who experience motor impairments during a TIA compared with those individuals who have no motor impairments.ConclusionThe presence of motor impairments during TIA is a significantly high-risk clinical characteristic for a subsequent stroke. The current evidence for motor impairments following TIA relies exclusively on the clinical reports of unilateral motor weakness. A comprehensive examination of motor impairments in TIA will enhance TIA prognosis and restoration of residual motor impairments. |
| first_indexed | 2024-12-21T20:41:59Z |
| format | Article |
| id | doaj.art-0e320c3feeb04da0b1fa051d7a24a6ea |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-21T20:41:59Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0e320c3feeb04da0b1fa051d7a24a6ea2022-12-21T18:50:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-06-01810.3389/fneur.2017.00243257415Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-AnalysisNeha Lodha0Jane Harrell1Stephan Eisenschenk2Evangelos A. Christou3Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, United StatesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesDepartment of Neurology, University of Florida, Gainesville, FL, United StatesDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United StatesBackground and purposeTransient ischemic attack (TIA) increases the risk for a subsequent stroke. Typical symptoms include motor weakness, gait disturbance, and loss of coordination. The association between the presence of motor impairments during a TIA and the chances of a subsequent stroke has not been examined. In the current meta-analysis, we examine whether the odds of a stroke are greater in TIA individuals who experience motor impairments as compared with those who do not experience motor impairments.MethodsWe conducted a systematic search of electronic databases as well as manual searches of the reference lists of retrieved articles. The meta-analysis included studies that reported an odds ratio relating motor impairments to a subsequent stroke, or the number of individuals with or without motor impairments who experienced a subsequent stroke. We examined these studies using rigorous meta-analysis techniques including random effects model, forest and funnel plots, I2, publication bias, and fail-safe analysis.ResultsTwenty-four studies with 15,129 participants from North America, Australia, Asia, and Europe qualified for inclusion. An odds ratio of 2.11 (95% CI, 1.67–2.65, p = 0.000) suggested that the chances of a subsequent stroke are increased by twofolds in individuals who experience motor impairments during a TIA compared with those individuals who have no motor impairments.ConclusionThe presence of motor impairments during TIA is a significantly high-risk clinical characteristic for a subsequent stroke. The current evidence for motor impairments following TIA relies exclusively on the clinical reports of unilateral motor weakness. A comprehensive examination of motor impairments in TIA will enhance TIA prognosis and restoration of residual motor impairments.http://journal.frontiersin.org/article/10.3389/fneur.2017.00243/fulltransient ischemic attackmotor impairmentsstrokeodds ratiometa-analysis |
| spellingShingle | Neha Lodha Jane Harrell Stephan Eisenschenk Evangelos A. Christou Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis Frontiers in Neurology transient ischemic attack motor impairments stroke odds ratio meta-analysis |
| title | Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis |
| title_full | Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis |
| title_fullStr | Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis |
| title_full_unstemmed | Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis |
| title_short | Motor Impairments in Transient Ischemic Attack Increase the Odds of a Subsequent Stroke: A Meta-Analysis |
| title_sort | motor impairments in transient ischemic attack increase the odds of a subsequent stroke a meta analysis |
| topic | transient ischemic attack motor impairments stroke odds ratio meta-analysis |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00243/full |
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