The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation
UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced alle...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/1/1 |
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| author | Thanh Sang Vo Se-Kwon Kim BoMi Ryu Dai Hung Ngo Na-Young Yoon Long Giang Bach Nguyen Thi Nhat Hang Dai Nghiep Ngo |
| author_facet | Thanh Sang Vo Se-Kwon Kim BoMi Ryu Dai Hung Ngo Na-Young Yoon Long Giang Bach Nguyen Thi Nhat Hang Dai Nghiep Ngo |
| author_sort | Thanh Sang Vo |
| collection | DOAJ |
| description | UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction. |
| first_indexed | 2024-04-11T11:03:42Z |
| format | Article |
| id | doaj.art-0e332d243d26446fa051292daaca45ac |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T11:03:42Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-0e332d243d26446fa051292daaca45ac2022-12-22T04:28:26ZengMDPI AGMarine Drugs1660-33972018-01-01161110.3390/md16010001md16010001The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell DegranulationThanh Sang Vo0Se-Kwon Kim1BoMi Ryu2Dai Hung Ngo3Na-Young Yoon4Long Giang Bach5Nguyen Thi Nhat Hang6Dai Nghiep Ngo7NTT Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, VietnamDepartment of Marine Life Science, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 606-791, KoreaSchool of Pharmacy, the University of Queensland, Brisbane QLD 4072, AustraliaFaculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, VietnamFood and Safety Research Center, National Fisheries Research & Development, Busan 46083, KoreaDepartment of Science and Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, VietnamFaculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, VietnamDepartment of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, VietnamUV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction.http://www.mdpi.com/1660-3397/16/1/1Ecklonia stoloniferaphlorotanninFucofuroeckol-Aanti-allergydegranulationmast cells |
| spellingShingle | Thanh Sang Vo Se-Kwon Kim BoMi Ryu Dai Hung Ngo Na-Young Yoon Long Giang Bach Nguyen Thi Nhat Hang Dai Nghiep Ngo The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation Marine Drugs Ecklonia stolonifera phlorotannin Fucofuroeckol-A anti-allergy degranulation mast cells |
| title | The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation |
| title_full | The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation |
| title_fullStr | The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation |
| title_full_unstemmed | The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation |
| title_short | The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation |
| title_sort | suppressive activity of fucofuroeckol a derived from brown algal ecklonia stolonifera okamura on uvb induced mast cell degranulation |
| topic | Ecklonia stolonifera phlorotannin Fucofuroeckol-A anti-allergy degranulation mast cells |
| url | http://www.mdpi.com/1660-3397/16/1/1 |
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