Adenoviruses Expressing PDX-1, BETA2/NeuroD and MafA Induces the Transdifferentiation of Porcine Neonatal Pancreas Cell Clusters and Adult Pig Pancreatic Cells into Beta-Cells

Adenoviruses Expressing PDX-1, BETA2/NeuroD and MafA Induces the Transdifferentiation of Porcine Neonatal Pancreas Cell Clusters and Adult Pig Pancreatic Cells into Beta-Cells

BackgroundA limitation in the number of insulin-producing pancreatic beta-cells is a special feature of diabetes. The identification of alternative sources for the induction of insulin-producing surrogate beta-cells is a matter of profound importance. PDX-1/VP16, BETA2/NeuroD, and MafA overexpressio...

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Bibliographic Details
Main Authors: Young-Hye You, Dong-Sik Ham, Heon-Seok Park, Marie Rhee, Ji-Won Kim, Kun-Ho Yoon
Format: Article
Language:English
Published: Korean Diabetes Association 2011-04-01
Series:Diabetes & Metabolism Journal
Subjects:
Ad-BETA2/NeuroD
Ad-MafA
Ad-PDX-1/VP16
Beta-cell
Neonatal pig cell clusters
Pancreatic exocrine cell
Transdifferentiation
Transplantation
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-119.pdf

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