Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon
Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, malaria and hepatitis (B & C) in rural Cameroo...
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02827/full |
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| author | Severin Donald Kamdem Severin Donald Kamdem Severin Donald Kamdem Francis Konhawa Erve Martial Kuemkon Leonel Meyo Kamguia Gladys K. Tchanana Gladys K. Tchanana Frungwa Nche Alim Oumarou Mamadou Hamza Yasmine Ouratou Mariette Nzoku Tcheutchoua René Ghislain Essomba René Ghislain Essomba Marie Paule Ngogang Michel Kengne Palmer Masumbe Netongo Palmer Masumbe Netongo Bienvenu Etogo Ondigui Marie Claire Okomo Assoumou Frank Brombacher Frank Brombacher Frank Brombacher Frank Brombacher Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono |
| author_facet | Severin Donald Kamdem Severin Donald Kamdem Severin Donald Kamdem Francis Konhawa Erve Martial Kuemkon Leonel Meyo Kamguia Gladys K. Tchanana Gladys K. Tchanana Frungwa Nche Alim Oumarou Mamadou Hamza Yasmine Ouratou Mariette Nzoku Tcheutchoua René Ghislain Essomba René Ghislain Essomba Marie Paule Ngogang Michel Kengne Palmer Masumbe Netongo Palmer Masumbe Netongo Bienvenu Etogo Ondigui Marie Claire Okomo Assoumou Frank Brombacher Frank Brombacher Frank Brombacher Frank Brombacher Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono |
| author_sort | Severin Donald Kamdem |
| collection | DOAJ |
| description | Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, malaria and hepatitis (B & C) in rural Cameroon.Methods: A cross-sectional study enrolling schoolchildren from 5 public schools was conducted. Single schistosomiasis, malaria and hepatitis infections or co-infections were assessed by kato katz, microscopy, and rapid diagnostic tests, respectively. Hepatic fibrosis was assessed by ultrasound according to WHO Niamey guidelines and plasma levels of Interleukin 33 were determined by ELISA. All statistics were performed using R studio software.Principal findings: We found a prevalence of 13.5% (37/275), 18.2% (50/275), and 8% (22/275), respectively for schistosomiasis, malaria and hepatitis (B or C) single infections. Only 7.6% (21/275) of co-infections were reported. Although Plasma IL-33 showed a minimal negative risk for schistosomiasis infection (AOR 0.99; 95% CI 0.97–1.01), S. mansoni infected participants had lower levels of plasma IL-33 (p = 0.003) which decreased significantly as eggs burdens increased (p = 0.01) with a negative Pearson coefficient of r = −0.22. Hepatic fibrosis occurred in 47.3% (130/275) of our study population independently from plasma levels of IL-33 (AOR 1.00; 95% CI 0.99–1.01).Conclusion/Significance: Our data failed to show an association between plasma IL-33 levels and liver disease but convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area. |
| first_indexed | 2024-12-11T03:17:01Z |
| format | Article |
| id | doaj.art-0e366057631b406ca826fbf10377a024 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T03:17:01Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0e366057631b406ca826fbf10377a0242022-12-22T01:22:43ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02827491578Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural CameroonSeverin Donald Kamdem0Severin Donald Kamdem1Severin Donald Kamdem2Francis Konhawa3Erve Martial Kuemkon4Leonel Meyo Kamguia5Gladys K. Tchanana6Gladys K. Tchanana7Frungwa Nche8Alim Oumarou9Mamadou Hamza10Yasmine Ouratou11Mariette Nzoku Tcheutchoua12René Ghislain Essomba13René Ghislain Essomba14Marie Paule Ngogang15Michel Kengne16Palmer Masumbe Netongo17Palmer Masumbe Netongo18Bienvenu Etogo Ondigui19Marie Claire Okomo Assoumou20Frank Brombacher21Frank Brombacher22Frank Brombacher23Frank Brombacher24Justin Komguep Nono25Justin Komguep Nono26Justin Komguep Nono27Justin Komguep Nono28Division of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South AfricaCape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South AfricaImmunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South AfricaSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonCIAB EXACT Medical Laboratory, Yaoundé, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, CameroonMinistry of Public Health, Yaoundé, CameroonMinistry of Public Health, Yaoundé, CameroonBiotechnology Centre, University of Yaoundé 1, Yaoundé, CameroonBiotechnology Centre, University of Yaoundé 1, Yaoundé, CameroonSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonNational Public Health Laboratory, Ministry of Public Health, Yaoundé, Cameroon0LABOREB, Yaoundé, CameroonSchool of Health Sciences, Catholic University of Central Africa, Yaoundé, CameroonBiotechnology Centre, University of Yaoundé 1, Yaoundé, Cameroon1Department of Biochemistry, University of Yaoundé 1, Yaoundé, CameroonNational Public Health Laboratory, Ministry of Public Health, Yaoundé, CameroonNational Public Health Laboratory, Ministry of Public Health, Yaoundé, CameroonDivision of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South AfricaCape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South AfricaImmunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South Africa2Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South AfricaDivision of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South AfricaCape Town Component, International Centre for Genetic Engineering and Biotechnology, Cape Town, South AfricaImmunology of Infectious Diseases Unit, South African Medical Research Centre, Cape Town, South Africa3The Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies, Ministry of Scientific Research and Innovation, Yaoundé, CameroonBackground: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, malaria and hepatitis (B & C) in rural Cameroon.Methods: A cross-sectional study enrolling schoolchildren from 5 public schools was conducted. Single schistosomiasis, malaria and hepatitis infections or co-infections were assessed by kato katz, microscopy, and rapid diagnostic tests, respectively. Hepatic fibrosis was assessed by ultrasound according to WHO Niamey guidelines and plasma levels of Interleukin 33 were determined by ELISA. All statistics were performed using R studio software.Principal findings: We found a prevalence of 13.5% (37/275), 18.2% (50/275), and 8% (22/275), respectively for schistosomiasis, malaria and hepatitis (B or C) single infections. Only 7.6% (21/275) of co-infections were reported. Although Plasma IL-33 showed a minimal negative risk for schistosomiasis infection (AOR 0.99; 95% CI 0.97–1.01), S. mansoni infected participants had lower levels of plasma IL-33 (p = 0.003) which decreased significantly as eggs burdens increased (p = 0.01) with a negative Pearson coefficient of r = −0.22. Hepatic fibrosis occurred in 47.3% (130/275) of our study population independently from plasma levels of IL-33 (AOR 1.00; 95% CI 0.99–1.01).Conclusion/Significance: Our data failed to show an association between plasma IL-33 levels and liver disease but convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area.https://www.frontiersin.org/article/10.3389/fimmu.2019.02827/fullschistosomiasismalariahepatitispolyparasitismcameroonschoolchildren |
| spellingShingle | Severin Donald Kamdem Severin Donald Kamdem Severin Donald Kamdem Francis Konhawa Erve Martial Kuemkon Leonel Meyo Kamguia Gladys K. Tchanana Gladys K. Tchanana Frungwa Nche Alim Oumarou Mamadou Hamza Yasmine Ouratou Mariette Nzoku Tcheutchoua René Ghislain Essomba René Ghislain Essomba Marie Paule Ngogang Michel Kengne Palmer Masumbe Netongo Palmer Masumbe Netongo Bienvenu Etogo Ondigui Marie Claire Okomo Assoumou Frank Brombacher Frank Brombacher Frank Brombacher Frank Brombacher Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono Justin Komguep Nono Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon Frontiers in Immunology schistosomiasis malaria hepatitis polyparasitism cameroon schoolchildren |
| title | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon |
| title_full | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon |
| title_fullStr | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon |
| title_full_unstemmed | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon |
| title_short | Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon |
| title_sort | negative association of interleukin 33 plasma levels and schistosomiasis infection in a site of polyparasitism in rural cameroon |
| topic | schistosomiasis malaria hepatitis polyparasitism cameroon schoolchildren |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02827/full |
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