Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines

Pharmacological Inhibition of Amyloidogenic APP Processing and Knock-Down of APP in Primary Human Macrophages Impairs the Secretion of Cytokines

It has been previously shown that the amyloid precursor protein (APP) support the innate immune defense as an immune receptor. Amyloid β (Aβ) peptides seem to have properties of an antimicrobial peptide and can act as opsonines. In APP-deficient mouse models, a reduced secretion of cytokines has bee...

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Bibliographic Details
Main Authors: Philipp Spitzer, Matthias Walter, Caroline Göth, Timo Jan Oberstein, Philipp Linning, Hans-Joachim Knölker, Johannes Kornhuber, Juan Manuel Maler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
amyloid precursor protein
amyloid
Abeta
Alzheimer
cytokine
immune system
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01967/full

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