Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease
Abstract Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01730-2 |
| _version_ | 1797952668582281216 |
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| author | Eerde H. Weening Ali A. Al-Mubarak Martin M. Dokter Kenneth Dickstein Chim C. Lang Leong L. Ng Marco Metra Dirk J. van Veldhuisen Daan J. Touw Rudolf A. de Boer Ron T. Gansevoort Adriaan A. Voors Stephan J. L. Bakker Peter van der Meer Nils Bomer |
| author_facet | Eerde H. Weening Ali A. Al-Mubarak Martin M. Dokter Kenneth Dickstein Chim C. Lang Leong L. Ng Marco Metra Dirk J. van Veldhuisen Daan J. Touw Rudolf A. de Boer Ron T. Gansevoort Adriaan A. Voors Stephan J. L. Bakker Peter van der Meer Nils Bomer |
| author_sort | Eerde H. Weening |
| collection | DOAJ |
| description | Abstract Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes. Objective Our objective was to elucidate sex-specific, cross-sectional phenotypic differences in the association of serum selenium concentrations with parameters of metabolic syndrome and HF. Methods We investigated data from individuals from a community-based cohort (PREVEND; N = 4288) and heart failure cohort (BIOSTAT-CHF; N = 1994). In both populations, cross-sectional analyses were performed for potential interaction (p < 0.1) between sex and serum selenium with overlapping signs and clinical parameters of the metabolic syndrome and HF. Results Baseline selenium levels of the total cohort were similar between PREVEND (85.7 μg/L) and BIOSTAT-CHF (89.1 μg/L). Females with lower selenium levels had a higher BMI and increased prevalence of diabetes than females with higher selenium, in both PREVEND (pinteraction < 0.001; pinteraction = 0.040, resp.) and BIOSTAT-CHF (pinteraction = 0.021; pinteraction = 0.024, resp.), while opposite associations were observed for males. Additionally, in females, but not in males, lower selenium was associated with a higher prevalence of myocardial infarction (MI) in PREVEND (pinteraction = 0.021) and BIOSTAT-CHF (pinteraction = 0.084). Conclusion Lower selenium was associated with a higher BMI and increased prevalence of diabetes in females, opposite to males, and was also associated with more MI in females. Interventional studies are needed to validate this observation. |
| first_indexed | 2024-04-10T22:50:04Z |
| format | Article |
| id | doaj.art-0e391b3e786140c3859e2ca8f1016731 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-10T22:50:04Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-0e391b3e786140c3859e2ca8f10167312023-01-15T12:03:46ZengBMCCardiovascular Diabetology1475-28402023-01-0122111110.1186/s12933-022-01730-2Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart diseaseEerde H. Weening0Ali A. Al-Mubarak1Martin M. Dokter2Kenneth Dickstein3Chim C. Lang4Leong L. Ng5Marco Metra6Dirk J. van Veldhuisen7Daan J. Touw8Rudolf A. de Boer9Ron T. Gansevoort10Adriaan A. Voors11Stephan J. L. Bakker12Peter van der Meer13Nils Bomer14Department of Cardiology, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenUniversity of Bergen, Stavanger University HospitalDivision of Molecular & Clinical Medicine, University of DundeeDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital and NIHR Leicester Biomedical Research CentreCardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili, University of BresciaDepartment of Cardiology, University Medical Center Groningen, University of GroningenDepartment of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenDivision of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenDepartment of Cardiology, University Medical Center Groningen, University of GroningenAbstract Background Serum selenium levels have been associated with the incidence of heart failure (HF) and signs of the metabolic syndrome. In addition, notable differences have been reported between males and females in food intake and micronutrient metabolism, possibly explaining different health outcomes. Objective Our objective was to elucidate sex-specific, cross-sectional phenotypic differences in the association of serum selenium concentrations with parameters of metabolic syndrome and HF. Methods We investigated data from individuals from a community-based cohort (PREVEND; N = 4288) and heart failure cohort (BIOSTAT-CHF; N = 1994). In both populations, cross-sectional analyses were performed for potential interaction (p < 0.1) between sex and serum selenium with overlapping signs and clinical parameters of the metabolic syndrome and HF. Results Baseline selenium levels of the total cohort were similar between PREVEND (85.7 μg/L) and BIOSTAT-CHF (89.1 μg/L). Females with lower selenium levels had a higher BMI and increased prevalence of diabetes than females with higher selenium, in both PREVEND (pinteraction < 0.001; pinteraction = 0.040, resp.) and BIOSTAT-CHF (pinteraction = 0.021; pinteraction = 0.024, resp.), while opposite associations were observed for males. Additionally, in females, but not in males, lower selenium was associated with a higher prevalence of myocardial infarction (MI) in PREVEND (pinteraction = 0.021) and BIOSTAT-CHF (pinteraction = 0.084). Conclusion Lower selenium was associated with a higher BMI and increased prevalence of diabetes in females, opposite to males, and was also associated with more MI in females. Interventional studies are needed to validate this observation.https://doi.org/10.1186/s12933-022-01730-2Sexual dimorphismInteractionSeleniumMetabolic syndromeHeart failure |
| spellingShingle | Eerde H. Weening Ali A. Al-Mubarak Martin M. Dokter Kenneth Dickstein Chim C. Lang Leong L. Ng Marco Metra Dirk J. van Veldhuisen Daan J. Touw Rudolf A. de Boer Ron T. Gansevoort Adriaan A. Voors Stephan J. L. Bakker Peter van der Meer Nils Bomer Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease Cardiovascular Diabetology Sexual dimorphism Interaction Selenium Metabolic syndrome Heart failure |
| title | Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| title_full | Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| title_fullStr | Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| title_full_unstemmed | Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| title_short | Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| title_sort | sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease |
| topic | Sexual dimorphism Interaction Selenium Metabolic syndrome Heart failure |
| url | https://doi.org/10.1186/s12933-022-01730-2 |
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