Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases
Nanotechnology utilizes engineered materials and devices which function with biological systems at the molecular level and could transform the management of neurodegenerative diseases (NDs) by provoking, reacting to, and intermingling with target sites to stimulate physiological responses while mini...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00305/full |
| _version_ | 1818284541827088384 |
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| author | Ajay Kumar Ajay Kumar Ravi Kumar Chaudhary Rachita Singh Satya P. Singh Shao-Yu Wang Zheng-Yu Hoe Cheng-Tang Pan Yow-Ling Shiue Dong-Qing Wei Aman Chandra Kaushik Aman Chandra Kaushik Xiaofeng Dai |
| author_facet | Ajay Kumar Ajay Kumar Ravi Kumar Chaudhary Rachita Singh Satya P. Singh Shao-Yu Wang Zheng-Yu Hoe Cheng-Tang Pan Yow-Ling Shiue Dong-Qing Wei Aman Chandra Kaushik Aman Chandra Kaushik Xiaofeng Dai |
| author_sort | Ajay Kumar |
| collection | DOAJ |
| description | Nanotechnology utilizes engineered materials and devices which function with biological systems at the molecular level and could transform the management of neurodegenerative diseases (NDs) by provoking, reacting to, and intermingling with target sites to stimulate physiological responses while minimizing side effects. Blood–brain barrier (BBB) protects the brain from harmful agents, and transporting drugs across the BBB is a major challenge for diagnosis, targeting, and treatment of NDs. The BBB provides severe limitations for diagnosis and treatment of Alzheimer’s disease (AD), Parkinson’s disease (PD), and various other neurological diseases. Conventional drug delivery systems generally fail to cross the BBB, thus are inefficient in treatment. Although gradual development through research is ensuring the progress of nanotheranostic approaches from animal to human modeling, aspects of translational applicability and safety are a key concern. This demands a deep understanding of the interaction of body systems with nanomaterials. There are various plant-based nanobioactive compounds which are reported to have applicability in the diagnosis and treatment of these NDs. This review article provides an overview of applications of nanotheranostics in AD and PD. The review also discusses nano-enabled drug delivery systems and their current and potential applications for the treatment of various NDs. |
| first_indexed | 2024-12-13T00:54:27Z |
| format | Article |
| id | doaj.art-0e3a0b0f77cd47cc8f910e8bca6e7b93 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T00:54:27Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-0e3a0b0f77cd47cc8f910e8bca6e7b932022-12-22T00:04:50ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-04-011410.3389/fnins.2020.00305499726Nanotheranostic Applications for Detection and Targeting Neurodegenerative DiseasesAjay Kumar0Ajay Kumar1Ravi Kumar Chaudhary2Rachita Singh3Satya P. Singh4Shao-Yu Wang5Zheng-Yu Hoe6Cheng-Tang Pan7Yow-Ling Shiue8Dong-Qing Wei9Aman Chandra Kaushik10Aman Chandra Kaushik11Xiaofeng Dai12Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, TaiwanDepartment of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, TaiwanDepartment of Biotechnology, Institute of Applied Medicines & Research, Ghaziabad, IndiaDepartment of Electrical and Electronics Engineering, IIMT Engineering College, Uttar Pradesh Technical University, Meerut, IndiaSchool of Computer Science & Engineering, Nanyang Technological University, Singapore, SingaporeDepartment of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, TaiwanInstitute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, TaiwanKey Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaKey Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaWuxi School of Medicine, Jiangnan University, Wuxi, ChinaNanotechnology utilizes engineered materials and devices which function with biological systems at the molecular level and could transform the management of neurodegenerative diseases (NDs) by provoking, reacting to, and intermingling with target sites to stimulate physiological responses while minimizing side effects. Blood–brain barrier (BBB) protects the brain from harmful agents, and transporting drugs across the BBB is a major challenge for diagnosis, targeting, and treatment of NDs. The BBB provides severe limitations for diagnosis and treatment of Alzheimer’s disease (AD), Parkinson’s disease (PD), and various other neurological diseases. Conventional drug delivery systems generally fail to cross the BBB, thus are inefficient in treatment. Although gradual development through research is ensuring the progress of nanotheranostic approaches from animal to human modeling, aspects of translational applicability and safety are a key concern. This demands a deep understanding of the interaction of body systems with nanomaterials. There are various plant-based nanobioactive compounds which are reported to have applicability in the diagnosis and treatment of these NDs. This review article provides an overview of applications of nanotheranostics in AD and PD. The review also discusses nano-enabled drug delivery systems and their current and potential applications for the treatment of various NDs.https://www.frontiersin.org/article/10.3389/fnins.2020.00305/fullneurodegenerative disordersnanotheranosticsParkinson’s diseaseAlzheimer’s diseasenanocomposite |
| spellingShingle | Ajay Kumar Ajay Kumar Ravi Kumar Chaudhary Rachita Singh Satya P. Singh Shao-Yu Wang Zheng-Yu Hoe Cheng-Tang Pan Yow-Ling Shiue Dong-Qing Wei Aman Chandra Kaushik Aman Chandra Kaushik Xiaofeng Dai Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases Frontiers in Neuroscience neurodegenerative disorders nanotheranostics Parkinson’s disease Alzheimer’s disease nanocomposite |
| title | Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases |
| title_full | Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases |
| title_fullStr | Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases |
| title_full_unstemmed | Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases |
| title_short | Nanotheranostic Applications for Detection and Targeting Neurodegenerative Diseases |
| title_sort | nanotheranostic applications for detection and targeting neurodegenerative diseases |
| topic | neurodegenerative disorders nanotheranostics Parkinson’s disease Alzheimer’s disease nanocomposite |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00305/full |
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