Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Synthesis, In Vitro, In Vivo and In Silico Antidiabetic Bioassays of 4-Nitro(thio)phenoxyisobutyric Acids Acting as Unexpected PPARγ Modulators: An In Combo Study

Four isobutyric acids (two nitro and two acetamido derivatives) were prepared in two steps and characterized using spectral analysis. The mRNA concentrations of PPARγ and GLUT-4 (two proteins documented as key diabetes targets) were increased by 3T3-L1 adipocytes treated with compounds <b>1<...

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Bibliographic Details
Main Authors: Blanca Colin-Lozano, Héctor Torres-Gomez, Sergio Hidalgo-Figueroa, Fabiola Chávez-Silva, Samuel Estrada-Soto, Julio Cesar Almanza-Pérez, Gabriel Navarrete-Vazquez
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Pharmaceuticals
Subjects:
PPAR
drug design
diabetes
molecular dynamics
Online Access:https://www.mdpi.com/1424-8247/15/1/102

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