Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells

Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells

Ischemic stroke is the second leading cause of death worldwide. Following ischemic stroke, Neurovascular Unit (NVU) inflammation and peripheral leucocytes infiltration are major contributors to the extension of brain lesions. For a long time restricted to neurons, the 10 past years have shown the em...

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Bibliographic Details
Main Authors: Lucas Le Roy, Anne Letondor, Cloé Le Roux, Ahmed Amara, Serge Timsit
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
ischemic stroke
neurovascular unit
leucocytes
CDK
roscovitine
Online Access:https://www.mdpi.com/2073-4409/10/1/104

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