Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review
Rhabdomyolysis is a life-threatening syndrome associated with direct or indirect muscle damage that is rarely reported with dipeptidyl peptidase (DPP)-4 inhibitors. Here we presented a case in which a 58-year-old female suffered from severe swelling and pain in bilateral lower limbs and oliguria aft...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.955162/full |
| _version_ | 1811342342199705600 |
|---|---|
| author | Zhijia Tang Xiaofang Fan Zhen Feng Bing Han Nan Guo |
| author_facet | Zhijia Tang Xiaofang Fan Zhen Feng Bing Han Nan Guo |
| author_sort | Zhijia Tang |
| collection | DOAJ |
| description | Rhabdomyolysis is a life-threatening syndrome associated with direct or indirect muscle damage that is rarely reported with dipeptidyl peptidase (DPP)-4 inhibitors. Here we presented a case in which a 58-year-old female suffered from severe swelling and pain in bilateral lower limbs and oliguria after a suicidal vildagliptin overdose. Drug-induced rhabdomyolysis and drug-induced liver injury were diagnosed based on laboratory and radiological findings. The patient was treated with fluid resuscitation, insulin, electrolyte replacement, diuretics, urine alkalizing agents, anticoagulants, antioxidants, and 24-h bedside ECG monitoring and suicide prevention. After 20 days of hospitalization and close monitoring, the patient was discharged without sequelae. Risk factors, diagnostic criteria, disease mechanisms, and outcomes were also discussed. This case illustrated that overdose of oral anti-diabetic medications may result in clinically significant adverse events, such as rhabdomyolysis in this case with a DPP-4 inhibitor. Although the incidence is low, special attention should be paid to intentional or accidental exposure to anti-diabetic medications during suicide attempts, especially in depressed patients with diabetes. |
| first_indexed | 2024-04-13T19:09:54Z |
| format | Article |
| id | doaj.art-0e3cc9e0e896418eac2a38b902608e8b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T19:09:54Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-0e3cc9e0e896418eac2a38b902608e8b2022-12-22T02:33:53ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.955162955162Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature reviewZhijia Tang0Xiaofang Fan1Zhen Feng2Bing Han3Nan Guo4Minhang Hospital & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, ChinaDepartment of Endocrinology, Minhang Hospital, Shanghai, ChinaMinhang Hospital & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, ChinaMinhang Hospital & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, ChinaMinhang Hospital & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, ChinaRhabdomyolysis is a life-threatening syndrome associated with direct or indirect muscle damage that is rarely reported with dipeptidyl peptidase (DPP)-4 inhibitors. Here we presented a case in which a 58-year-old female suffered from severe swelling and pain in bilateral lower limbs and oliguria after a suicidal vildagliptin overdose. Drug-induced rhabdomyolysis and drug-induced liver injury were diagnosed based on laboratory and radiological findings. The patient was treated with fluid resuscitation, insulin, electrolyte replacement, diuretics, urine alkalizing agents, anticoagulants, antioxidants, and 24-h bedside ECG monitoring and suicide prevention. After 20 days of hospitalization and close monitoring, the patient was discharged without sequelae. Risk factors, diagnostic criteria, disease mechanisms, and outcomes were also discussed. This case illustrated that overdose of oral anti-diabetic medications may result in clinically significant adverse events, such as rhabdomyolysis in this case with a DPP-4 inhibitor. Although the incidence is low, special attention should be paid to intentional or accidental exposure to anti-diabetic medications during suicide attempts, especially in depressed patients with diabetes.https://www.frontiersin.org/articles/10.3389/fphar.2022.955162/fullvildagliptinrhabdomyolysisDPP-4 inhibitoroverdosecase report |
| spellingShingle | Zhijia Tang Xiaofang Fan Zhen Feng Bing Han Nan Guo Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review Frontiers in Pharmacology vildagliptin rhabdomyolysis DPP-4 inhibitor overdose case report |
| title | Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review |
| title_full | Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review |
| title_fullStr | Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review |
| title_full_unstemmed | Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review |
| title_short | Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review |
| title_sort | case report rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt a case report and brief literature review |
| topic | vildagliptin rhabdomyolysis DPP-4 inhibitor overdose case report |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.955162/full |
| work_keys_str_mv | AT zhijiatang casereportrhabdomyolysissecondarytovildagliptinoverdoseinasuicidalattemptacasereportandbriefliteraturereview AT xiaofangfan casereportrhabdomyolysissecondarytovildagliptinoverdoseinasuicidalattemptacasereportandbriefliteraturereview AT zhenfeng casereportrhabdomyolysissecondarytovildagliptinoverdoseinasuicidalattemptacasereportandbriefliteraturereview AT binghan casereportrhabdomyolysissecondarytovildagliptinoverdoseinasuicidalattemptacasereportandbriefliteraturereview AT nanguo casereportrhabdomyolysissecondarytovildagliptinoverdoseinasuicidalattemptacasereportandbriefliteraturereview |