Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models

Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models

Parkinsonian symptoms arise due to over-activity of the indirect striatal output pathway, and under-activity of the direct striatal output pathway. l-DOPA-induced dyskinesia (LID) is caused when the opposite circuitry problems are established, with the indirect pathway becoming underactive, and the...

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Bibliographic Details
Main Authors: Sherri L. Thiele, Betty Chen, Charlotte Lo, Tracey S. Gertler, Ruth Warre, James D. Surmeier, Jonathan M. Brotchie, Joanne E. Nash
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Dyskinesia
BAC transgenic mouse models
Slice electrophysiology
Striatum
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002356

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