CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1

CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1

Abstract Background Osteoporosis (OP) is the result of bone mass reduction and bone structure disorder. Bone marrow mesenchymal stem cells (BMSCs) are the main source of osteogenic precursor cells involved in adult bone remodeling. The involvement of the deubiquitinating enzyme CYLD in OP has recent...

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Bibliographic Details
Main Authors: Guiyong Jiang, Yu Cai, Duo Cheng, Hao Wang, Geyang Deng, Dayong Xiang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
CYLD
NLRP3
Osteoporosis
Pyroptosis
WNK1
Online Access:https://doi.org/10.1186/s13018-024-04675-2

Internet

https://doi.org/10.1186/s13018-024-04675-2

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