Non-adherence to topical treatments for actinic keratosis
Bav Shergill,1 Simon Zokaie,2 Alison J Carr3 1Department of Dermatology, Brighton and Sussex University Hospitals, Elm Grove, Brighton, UK; 2Leo Pharma, Princes Risborough, 3Hamell, London, UK Background: There is limited information on the patterns of use, adherence rates, and factors that impact...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-12-01
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| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/non-adherence-to-topical-treatments-for-actinic-keratosis-a15303 |
| _version_ | 1811297793412694016 |
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| author | Shergill B Zokaie S Carr AJ |
| author_facet | Shergill B Zokaie S Carr AJ |
| author_sort | Shergill B |
| collection | DOAJ |
| description | Bav Shergill,1 Simon Zokaie,2 Alison J Carr3 1Department of Dermatology, Brighton and Sussex University Hospitals, Elm Grove, Brighton, UK; 2Leo Pharma, Princes Risborough, 3Hamell, London, UK Background: There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK). Objectives: To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. Methods: A community-based, cross-sectional study was performed using a standardized questionnaire completed online or via telephone interview. Patients were stratified according to the presence of AK lesions on the scalp and/or other extremities; and presence of scarring resulting from treatment. Results: This study included 305 patients with AK who were currently using a patient-applied topical therapy for AK or had used one within the previous 12 months. In total, 88% (n = 268/305) of patients were either non-adherent, non-persistent or both non-adherent and non-persistent to topical therapy. Duration of treatment was associated with increasing rates of non-adherence (adjusted odds ratio [OR]; for treatment durations greater than 4 weeks, 2.2, P < 0.01): 52% of patients were non-adherent with 3–4 week treatment duration; 69% of patients with 4–8 week treatment duration; and 71% of patients with 6–12 week treatment duration. There were similar increases in non-persistence with increasing treatment duration (adjusted OR; for treatment durations greater than 4 weeks, 2.1, P < 0.05). Conclusion: This study found high rates of non-adherence and non-persistence in patients with AK. Duration of treatment was a significant factor contributing to non-adherence and non-persistence to topical treatments. Patient-applied topical therapies that require less frequent application and have shorter treatment duration may be associated with improved adherence rates. Keywords: patient compliance, chronic skin disease, treatment duration, patient behavior |
| first_indexed | 2024-04-13T06:10:25Z |
| format | Article |
| id | doaj.art-0e3df5a9216a40c4a0e42f0abc0764d4 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-04-13T06:10:25Z |
| publishDate | 2013-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-0e3df5a9216a40c4a0e42f0abc0764d42022-12-22T02:59:05ZengDove Medical PressPatient Preference and Adherence1177-889X2013-12-012014default354115303Non-adherence to topical treatments for actinic keratosisShergill BZokaie SCarr AJBav Shergill,1 Simon Zokaie,2 Alison J Carr3 1Department of Dermatology, Brighton and Sussex University Hospitals, Elm Grove, Brighton, UK; 2Leo Pharma, Princes Risborough, 3Hamell, London, UK Background: There is limited information on the patterns of use, adherence rates, and factors that impact adherence with topical treatments for actinic keratosis (AK). Objectives: To establish patterns of use and adherence with topical treatments for AK and to identify treatment-related factors that impact on adherence. Methods: A community-based, cross-sectional study was performed using a standardized questionnaire completed online or via telephone interview. Patients were stratified according to the presence of AK lesions on the scalp and/or other extremities; and presence of scarring resulting from treatment. Results: This study included 305 patients with AK who were currently using a patient-applied topical therapy for AK or had used one within the previous 12 months. In total, 88% (n = 268/305) of patients were either non-adherent, non-persistent or both non-adherent and non-persistent to topical therapy. Duration of treatment was associated with increasing rates of non-adherence (adjusted odds ratio [OR]; for treatment durations greater than 4 weeks, 2.2, P < 0.01): 52% of patients were non-adherent with 3–4 week treatment duration; 69% of patients with 4–8 week treatment duration; and 71% of patients with 6–12 week treatment duration. There were similar increases in non-persistence with increasing treatment duration (adjusted OR; for treatment durations greater than 4 weeks, 2.1, P < 0.05). Conclusion: This study found high rates of non-adherence and non-persistence in patients with AK. Duration of treatment was a significant factor contributing to non-adherence and non-persistence to topical treatments. Patient-applied topical therapies that require less frequent application and have shorter treatment duration may be associated with improved adherence rates. Keywords: patient compliance, chronic skin disease, treatment duration, patient behaviorhttp://www.dovepress.com/non-adherence-to-topical-treatments-for-actinic-keratosis-a15303 |
| spellingShingle | Shergill B Zokaie S Carr AJ Non-adherence to topical treatments for actinic keratosis Patient Preference and Adherence |
| title | Non-adherence to topical treatments for actinic keratosis |
| title_full | Non-adherence to topical treatments for actinic keratosis |
| title_fullStr | Non-adherence to topical treatments for actinic keratosis |
| title_full_unstemmed | Non-adherence to topical treatments for actinic keratosis |
| title_short | Non-adherence to topical treatments for actinic keratosis |
| title_sort | non adherence to topical treatments for actinic keratosis |
| url | http://www.dovepress.com/non-adherence-to-topical-treatments-for-actinic-keratosis-a15303 |
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