Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma

Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma

Despite the success of immune checkpoint inhibitors that target cytotoxic lymphocyte antigen-4 (CTLA-4) and programmed-cell-death-1 (PD-1) in the treatment of metastatic melanoma, there is still great need to develop robust options for patients who are refractory to first line immunotherapy. As such...

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Bibliographic Details
Main Authors: Peter Kar Han Lau, Carleen Cullinane, Susan Jackson, Rachael Walker, Lorey K. Smith, Alison Slater, Laura Kirby, Riyaben P. Patel, Bianca von Scheidt, Clare Y. Slaney, Grant A. McArthur, Karen E. Sheppard
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
melanoma
adoptive cell transfer
targeted therapy
cell cycle
immuno-oncology
Online Access:https://www.mdpi.com/2072-6694/13/24/6342

Internet

https://www.mdpi.com/2072-6694/13/24/6342

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