Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation
Transdermal administration of drugs is generally limited by the barrier function of the skin. Vesicular systems are one of the most controversial methods for transdermal delivery of active substances. The interest in designing transdermal delivery systems was relaunched after the discovery of elasti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=3;spage=138;epage=143;aulast=Rajan |
| _version_ | 1819261951448973312 |
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| author | Reshmy Rajan Shoma Jose V P Biju Mukund Deepa T Vasudevan |
| author_facet | Reshmy Rajan Shoma Jose V P Biju Mukund Deepa T Vasudevan |
| author_sort | Reshmy Rajan |
| collection | DOAJ |
| description | Transdermal administration of drugs is generally limited by the barrier function of the skin. Vesicular systems are one of the most controversial methods for transdermal delivery of active substances. The interest in designing transdermal delivery systems was relaunched after the discovery of elastic vesicles like transferosomes, ethosomes, cubosomes, phytosomes, etc. This paper presents the composition, mechanisms of penetration, manufacturing and characterization methods of transferosomes as transdermal delivery systems of active substances. For a drug to be absorbed and distributed into organs and tissues and eliminated from the body, it must pass through one or more biological membranes/barriers at various locations. Such a movement of drug across the membrane is called as drug transport. For the drugs to be delivered to the body, they should cross the membranous barrier. The concept of these delivery systems was designed in an attempt to concentrate the drug in the tissues of interest, while reducing the amount of drug in the remaining tissues. Hence, surrounding tissues are not affected by the drug. In addition, loss of drug does not happen due to localization of drug, leading to get maximum efficacy of the medication. Therefore, the phospholipid based carrier systems are of considerable interest in this era. |
| first_indexed | 2024-12-23T19:49:57Z |
| format | Article |
| id | doaj.art-0e3ed4df4c474f16a4d6c0c46c1df448 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-23T19:49:57Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-0e3ed4df4c474f16a4d6c0c46c1df4482022-12-21T17:33:25ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942011-01-012313814310.4103/2231-4040.85524Transferosomes - A vesicular transdermal delivery system for enhanced drug permeationReshmy RajanShoma JoseV P Biju MukundDeepa T VasudevanTransdermal administration of drugs is generally limited by the barrier function of the skin. Vesicular systems are one of the most controversial methods for transdermal delivery of active substances. The interest in designing transdermal delivery systems was relaunched after the discovery of elastic vesicles like transferosomes, ethosomes, cubosomes, phytosomes, etc. This paper presents the composition, mechanisms of penetration, manufacturing and characterization methods of transferosomes as transdermal delivery systems of active substances. For a drug to be absorbed and distributed into organs and tissues and eliminated from the body, it must pass through one or more biological membranes/barriers at various locations. Such a movement of drug across the membrane is called as drug transport. For the drugs to be delivered to the body, they should cross the membranous barrier. The concept of these delivery systems was designed in an attempt to concentrate the drug in the tissues of interest, while reducing the amount of drug in the remaining tissues. Hence, surrounding tissues are not affected by the drug. In addition, loss of drug does not happen due to localization of drug, leading to get maximum efficacy of the medication. Therefore, the phospholipid based carrier systems are of considerable interest in this era.http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=3;spage=138;epage=143;aulast=RajanLecithinstratum corneumsurfactanttransferosomesvesicles |
| spellingShingle | Reshmy Rajan Shoma Jose V P Biju Mukund Deepa T Vasudevan Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation Journal of Advanced Pharmaceutical Technology & Research Lecithin stratum corneum surfactant transferosomes vesicles |
| title | Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation |
| title_full | Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation |
| title_fullStr | Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation |
| title_full_unstemmed | Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation |
| title_short | Transferosomes - A vesicular transdermal delivery system for enhanced drug permeation |
| title_sort | transferosomes a vesicular transdermal delivery system for enhanced drug permeation |
| topic | Lecithin stratum corneum surfactant transferosomes vesicles |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2011;volume=2;issue=3;spage=138;epage=143;aulast=Rajan |
| work_keys_str_mv | AT reshmyrajan transferosomesavesiculartransdermaldeliverysystemforenhanceddrugpermeation AT shomajose transferosomesavesiculartransdermaldeliverysystemforenhanceddrugpermeation AT vpbijumukund transferosomesavesiculartransdermaldeliverysystemforenhanceddrugpermeation AT deepatvasudevan transferosomesavesiculartransdermaldeliverysystemforenhanceddrugpermeation |