Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia
<b>Background & objectives:</b> There is lack of adequate information on the association between severe malaria and some human genetic markers like ABO blood types. The study was undertaken to evaluate the association between severe malaria infection and ABO blood types among febrile...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-12-01
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| Series: | Journal of Vector Borne Diseases |
| Subjects: | |
| Online Access: | http://www.mrcindia.org/journal/issues/504292.pdf |
| _version_ | 1818033409077805056 |
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| author | Hailu Tadesse Kebede Tadesse |
| author_facet | Hailu Tadesse Kebede Tadesse |
| author_sort | Hailu Tadesse |
| collection | DOAJ |
| description | <b>Background & objectives:</b> There is lack of adequate information on the association between severe malaria and some human genetic markers like ABO blood types. The study was undertaken to evaluate the association between severe malaria infection and ABO blood types among febrile patients attending Felegeselam Health Center, northwestern Ethiopia.
<b>Methods:</b> A total of 398 febrile patients were examined for malaria and tested for ABO blood groups in December 2011. The blood samples were collected by finger pricking, stained with Giemsa and slides were examined microscopically. ABO blood group was determined by agglutination test using agglutinating A and B monoclonal anti-sera together with parasite load count. Chi-square and ANOVA tests were used to assess the difference between frequencies and means, respectively.
<b>Results:</b> Out of 398 acute febrile patients, 201 (50.5%) were found to be infected with <i>Plasmodium</i> parasites. Of which 194 (48.74%) and 7 (1.76%) belong to <i>Plasmodium falciparum</i> and <i>P. vivax</i>, respectively. The distribution of ABO blood groups was O (46%), A (27.1%), B (23.1%) and AB (3.8%). The percentage of severe malaria with respect to blood group A, B, AB and O was found to be 40, 34.1, 14.3 and 5.1%, respectively. The association of severe malaria with non 'O' blood types was statistically significant (χ2 = 31.246, <i>p</i> <0.01).
<b>Interpretation & conclusion:</b> The present findings indicate that individuals with blood groups A, B and AB are more susceptible for severe malaria infection than blood group O. |
| first_indexed | 2024-12-10T06:22:48Z |
| format | Article |
| id | doaj.art-0e3fc53563c24d93bbd447bfb68b4d0c |
| institution | Directory Open Access Journal |
| issn | 0972-9062 0972-9062 |
| language | English |
| last_indexed | 2024-12-10T06:22:48Z |
| publishDate | 2013-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Vector Borne Diseases |
| spelling | doaj.art-0e3fc53563c24d93bbd447bfb68b4d0c2022-12-22T01:59:18ZengWolters Kluwer Medknow PublicationsJournal of Vector Borne Diseases0972-90620972-90622013-12-01504292296Assessing the association of severe malaria infection and ABO blood groups in northwestern EthiopiaHailu TadesseKebede Tadesse<b>Background & objectives:</b> There is lack of adequate information on the association between severe malaria and some human genetic markers like ABO blood types. The study was undertaken to evaluate the association between severe malaria infection and ABO blood types among febrile patients attending Felegeselam Health Center, northwestern Ethiopia. <b>Methods:</b> A total of 398 febrile patients were examined for malaria and tested for ABO blood groups in December 2011. The blood samples were collected by finger pricking, stained with Giemsa and slides were examined microscopically. ABO blood group was determined by agglutination test using agglutinating A and B monoclonal anti-sera together with parasite load count. Chi-square and ANOVA tests were used to assess the difference between frequencies and means, respectively. <b>Results:</b> Out of 398 acute febrile patients, 201 (50.5%) were found to be infected with <i>Plasmodium</i> parasites. Of which 194 (48.74%) and 7 (1.76%) belong to <i>Plasmodium falciparum</i> and <i>P. vivax</i>, respectively. The distribution of ABO blood groups was O (46%), A (27.1%), B (23.1%) and AB (3.8%). The percentage of severe malaria with respect to blood group A, B, AB and O was found to be 40, 34.1, 14.3 and 5.1%, respectively. The association of severe malaria with non 'O' blood types was statistically significant (χ2 = 31.246, <i>p</i> <0.01). <b>Interpretation & conclusion:</b> The present findings indicate that individuals with blood groups A, B and AB are more susceptible for severe malaria infection than blood group O.http://www.mrcindia.org/journal/issues/504292.pdfABO blood group; acute febrile illness; Ethiopia<i>; Plasmodium falciparum; P. vivax;</i> severe malaria |
| spellingShingle | Hailu Tadesse Kebede Tadesse Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia Journal of Vector Borne Diseases ABO blood group; acute febrile illness; Ethiopia<i>; Plasmodium falciparum; P. vivax;</i> severe malaria |
| title | Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia |
| title_full | Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia |
| title_fullStr | Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia |
| title_full_unstemmed | Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia |
| title_short | Assessing the association of severe malaria infection and ABO blood groups in northwestern Ethiopia |
| title_sort | assessing the association of severe malaria infection and abo blood groups in northwestern ethiopia |
| topic | ABO blood group; acute febrile illness; Ethiopia<i>; Plasmodium falciparum; P. vivax;</i> severe malaria |
| url | http://www.mrcindia.org/journal/issues/504292.pdf |
| work_keys_str_mv | AT hailutadesse assessingtheassociationofseveremalariainfectionandabobloodgroupsinnorthwesternethiopia AT kebedetadesse assessingtheassociationofseveremalariainfectionandabobloodgroupsinnorthwesternethiopia |