Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance.
Cholera burden in Africa remains unknown, often because of weak national surveillance systems. We analyzed data from the African Cholera Surveillance Network (www.africhol.org).During June 2011-December 2013, we conducted enhanced surveillance in seven zones and four outbreak sites in Togo, the Demo...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-05-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4871502?pdf=render |
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| author | Delphine Sauvageot Berthe-Marie Njanpop-Lafourcade Laurent Akilimali Jean-Claude Anne Pawou Bidjada Didier Bompangue Godfrey Bwire Daouda Coulibaly Liliana Dengo-Baloi Mireille Dosso Christopher Garimoi Orach Dorteia Inguane Atek Kagirita Adele Kacou-N'Douba Sakoba Keita Abiba Kere Banla Yao Jean-Pierre Kouame Dadja Essoya Landoh Jose Paulo Langa Issa Makumbi Berthe Miwanda Muggaga Malimbo Guy Mutombo Annie Mutombo Emilienne Niamke NGuetta Mamadou Saliou Veronique Sarr Raphael Kakongo Senga Fode Sory Cynthia Sema Ouyi Valentin Tante Bradford D Gessner Martin A Mengel |
| author_facet | Delphine Sauvageot Berthe-Marie Njanpop-Lafourcade Laurent Akilimali Jean-Claude Anne Pawou Bidjada Didier Bompangue Godfrey Bwire Daouda Coulibaly Liliana Dengo-Baloi Mireille Dosso Christopher Garimoi Orach Dorteia Inguane Atek Kagirita Adele Kacou-N'Douba Sakoba Keita Abiba Kere Banla Yao Jean-Pierre Kouame Dadja Essoya Landoh Jose Paulo Langa Issa Makumbi Berthe Miwanda Muggaga Malimbo Guy Mutombo Annie Mutombo Emilienne Niamke NGuetta Mamadou Saliou Veronique Sarr Raphael Kakongo Senga Fode Sory Cynthia Sema Ouyi Valentin Tante Bradford D Gessner Martin A Mengel |
| author_sort | Delphine Sauvageot |
| collection | DOAJ |
| description | Cholera burden in Africa remains unknown, often because of weak national surveillance systems. We analyzed data from the African Cholera Surveillance Network (www.africhol.org).During June 2011-December 2013, we conducted enhanced surveillance in seven zones and four outbreak sites in Togo, the Democratic Republic of Congo (DRC), Guinea, Uganda, Mozambique and Cote d'Ivoire. All health facilities treating cholera cases were included. Cholera incidences were calculated using culture-confirmed cholera cases and culture-confirmed cholera cases corrected for lack of culture testing usually due to overwhelmed health systems and imperfect test sensitivity. Of 13,377 reported suspected cases, 34% occurred in Conakry, Guinea, 47% in Goma, DRC, and 19% in the remaining sites. From 0-40% of suspected cases were aged under five years and from 0.3-86% had rice water stools. Within surveillance zones, 0-37% of suspected cases had confirmed cholera compared to 27-38% during outbreaks. Annual confirmed incidence per 10,000 population was <0.5 in surveillance zones, except Goma where it was 4.6. Goma and Conakry had corrected incidences of 20.2 and 5.8 respectively, while the other zones a median of 0.3. During outbreaks, corrected incidence varied from 2.6 to 13.0. Case fatality ratios ranged from 0-10% (median, 1%) by country.Across different African epidemiological contexts, substantial variation occurred in cholera incidence, age distribution, clinical presentation, culture confirmation, and testing frequency. These results can help guide preventive activities, including vaccine use. |
| first_indexed | 2024-12-20T06:02:18Z |
| format | Article |
| id | doaj.art-0e42682e713d48ecb085f35f0ae3982b |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-20T06:02:18Z |
| publishDate | 2016-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-0e42682e713d48ecb085f35f0ae3982b2022-12-21T19:50:53ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352016-05-01105e000467910.1371/journal.pntd.0004679Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance.Delphine SauvageotBerthe-Marie Njanpop-LafourcadeLaurent AkilimaliJean-Claude AnnePawou BidjadaDidier BompangueGodfrey BwireDaouda CoulibalyLiliana Dengo-BaloiMireille DossoChristopher Garimoi OrachDorteia InguaneAtek KagiritaAdele Kacou-N'DoubaSakoba KeitaAbiba Kere BanlaYao Jean-Pierre KouameDadja Essoya LandohJose Paulo LangaIssa MakumbiBerthe MiwandaMuggaga MalimboGuy MutomboAnnie MutomboEmilienne Niamke NGuettaMamadou SaliouVeronique SarrRaphael Kakongo SengaFode SoryCynthia SemaOuyi Valentin TanteBradford D GessnerMartin A MengelCholera burden in Africa remains unknown, often because of weak national surveillance systems. We analyzed data from the African Cholera Surveillance Network (www.africhol.org).During June 2011-December 2013, we conducted enhanced surveillance in seven zones and four outbreak sites in Togo, the Democratic Republic of Congo (DRC), Guinea, Uganda, Mozambique and Cote d'Ivoire. All health facilities treating cholera cases were included. Cholera incidences were calculated using culture-confirmed cholera cases and culture-confirmed cholera cases corrected for lack of culture testing usually due to overwhelmed health systems and imperfect test sensitivity. Of 13,377 reported suspected cases, 34% occurred in Conakry, Guinea, 47% in Goma, DRC, and 19% in the remaining sites. From 0-40% of suspected cases were aged under five years and from 0.3-86% had rice water stools. Within surveillance zones, 0-37% of suspected cases had confirmed cholera compared to 27-38% during outbreaks. Annual confirmed incidence per 10,000 population was <0.5 in surveillance zones, except Goma where it was 4.6. Goma and Conakry had corrected incidences of 20.2 and 5.8 respectively, while the other zones a median of 0.3. During outbreaks, corrected incidence varied from 2.6 to 13.0. Case fatality ratios ranged from 0-10% (median, 1%) by country.Across different African epidemiological contexts, substantial variation occurred in cholera incidence, age distribution, clinical presentation, culture confirmation, and testing frequency. These results can help guide preventive activities, including vaccine use.http://europepmc.org/articles/PMC4871502?pdf=render |
| spellingShingle | Delphine Sauvageot Berthe-Marie Njanpop-Lafourcade Laurent Akilimali Jean-Claude Anne Pawou Bidjada Didier Bompangue Godfrey Bwire Daouda Coulibaly Liliana Dengo-Baloi Mireille Dosso Christopher Garimoi Orach Dorteia Inguane Atek Kagirita Adele Kacou-N'Douba Sakoba Keita Abiba Kere Banla Yao Jean-Pierre Kouame Dadja Essoya Landoh Jose Paulo Langa Issa Makumbi Berthe Miwanda Muggaga Malimbo Guy Mutombo Annie Mutombo Emilienne Niamke NGuetta Mamadou Saliou Veronique Sarr Raphael Kakongo Senga Fode Sory Cynthia Sema Ouyi Valentin Tante Bradford D Gessner Martin A Mengel Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. PLoS Neglected Tropical Diseases |
| title | Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. |
| title_full | Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. |
| title_fullStr | Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. |
| title_full_unstemmed | Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. |
| title_short | Cholera Incidence and Mortality in Sub-Saharan African Sites during Multi-country Surveillance. |
| title_sort | cholera incidence and mortality in sub saharan african sites during multi country surveillance |
| url | http://europepmc.org/articles/PMC4871502?pdf=render |
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