Two Furanosesterterpenoids from the Sponge Luffariella variabilis
Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations...
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MDPI AG
2017-08-01
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Series: | Marine Drugs |
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Online Access: | https://www.mdpi.com/1660-3397/15/8/249 |
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author | Peni Ahmadi Masahiro Higashi Nicole J. de Voogd Junichi Tanaka |
author_facet | Peni Ahmadi Masahiro Higashi Nicole J. de Voogd Junichi Tanaka |
author_sort | Peni Ahmadi |
collection | DOAJ |
description | Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells. |
first_indexed | 2024-04-11T20:49:45Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 1660-3397 |
language | English |
last_indexed | 2024-04-11T20:49:45Z |
publishDate | 2017-08-01 |
publisher | MDPI AG |
record_format | Article |
series | Marine Drugs |
spelling | doaj.art-0e42f987c9d24821a798aa85409476742022-12-22T04:03:52ZengMDPI AGMarine Drugs1660-33972017-08-0115824910.3390/md15080249md15080249Two Furanosesterterpenoids from the Sponge Luffariella variabilisPeni Ahmadi0Masahiro Higashi1Nicole J. de Voogd2Junichi Tanaka3Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanDepartment of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanNaturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The NetherlandsDepartment of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanTwo new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.https://www.mdpi.com/1660-3397/15/8/249sesterterpenoidspongecytotoxicity |
spellingShingle | Peni Ahmadi Masahiro Higashi Nicole J. de Voogd Junichi Tanaka Two Furanosesterterpenoids from the Sponge Luffariella variabilis Marine Drugs sesterterpenoid sponge cytotoxicity |
title | Two Furanosesterterpenoids from the Sponge Luffariella variabilis |
title_full | Two Furanosesterterpenoids from the Sponge Luffariella variabilis |
title_fullStr | Two Furanosesterterpenoids from the Sponge Luffariella variabilis |
title_full_unstemmed | Two Furanosesterterpenoids from the Sponge Luffariella variabilis |
title_short | Two Furanosesterterpenoids from the Sponge Luffariella variabilis |
title_sort | two furanosesterterpenoids from the sponge luffariella variabilis |
topic | sesterterpenoid sponge cytotoxicity |
url | https://www.mdpi.com/1660-3397/15/8/249 |
work_keys_str_mv | AT peniahmadi twofuranosesterterpenoidsfromthespongeluffariellavariabilis AT masahirohigashi twofuranosesterterpenoidsfromthespongeluffariellavariabilis AT nicolejdevoogd twofuranosesterterpenoidsfromthespongeluffariellavariabilis AT junichitanaka twofuranosesterterpenoidsfromthespongeluffariellavariabilis |