Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations...

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Main Authors: Peni Ahmadi, Masahiro Higashi, Nicole J. de Voogd, Junichi Tanaka
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Marine Drugs
Subjects:
Online Access:https://www.mdpi.com/1660-3397/15/8/249
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author Peni Ahmadi
Masahiro Higashi
Nicole J. de Voogd
Junichi Tanaka
author_facet Peni Ahmadi
Masahiro Higashi
Nicole J. de Voogd
Junichi Tanaka
author_sort Peni Ahmadi
collection DOAJ
description Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.
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spelling doaj.art-0e42f987c9d24821a798aa85409476742022-12-22T04:03:52ZengMDPI AGMarine Drugs1660-33972017-08-0115824910.3390/md15080249md15080249Two Furanosesterterpenoids from the Sponge Luffariella variabilisPeni Ahmadi0Masahiro Higashi1Nicole J. de Voogd2Junichi Tanaka3Department of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanDepartment of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanNaturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The NetherlandsDepartment of Chemistry, Biology and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, JapanTwo new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC50 1.0 µM against NBT-T2 cells.https://www.mdpi.com/1660-3397/15/8/249sesterterpenoidspongecytotoxicity
spellingShingle Peni Ahmadi
Masahiro Higashi
Nicole J. de Voogd
Junichi Tanaka
Two Furanosesterterpenoids from the Sponge Luffariella variabilis
Marine Drugs
sesterterpenoid
sponge
cytotoxicity
title Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_full Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_fullStr Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_full_unstemmed Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_short Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_sort two furanosesterterpenoids from the sponge luffariella variabilis
topic sesterterpenoid
sponge
cytotoxicity
url https://www.mdpi.com/1660-3397/15/8/249
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