High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice
Abstract Background Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods In our study, nor...
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BMC
2022-06-01
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Series: | Nutrition & Metabolism |
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Online Access: | https://doi.org/10.1186/s12986-022-00675-3 |
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author | Yinan Hua Jingyi Shen Rong Fan Rong Xiao Weiwei Ma |
author_facet | Yinan Hua Jingyi Shen Rong Fan Rong Xiao Weiwei Ma |
author_sort | Yinan Hua |
collection | DOAJ |
description | Abstract Background Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods In our study, normal male C57BL/6J mice were fed to multiple high fatty acid diets (long-chain and medium-chain saturated fatty acid, LCSFA and MCSFA group; n-3 and n-6 polyunsaturated fatty acid, n-3 and n-6 PUFA group; monounsaturated fatty acid, MUFA group; trans fatty acid, TFA group) and a basic diet (control, CON group) for 19 weeks. To investigate the effects of high-fat diets on metabolic responses of gut-brain axis in obese mice, blood lipids were detected by fast gas chromatography, and related proteins in brain and intestine were detected using Western blotting, ELISA, and immunochemistry analysis. Results All high-fat diets regardless of their fatty acid composition induced obesity, lipid disorders, intestinal barrier dysfunction, and changes in gut-brain axis related factors except basal diet in mice. For example, the protein expression of zonula occludens-1 (ZO-1) in ileum in the n-3 PUFA group was higher than that in the MCSFA group (P < 0.05). The expressions of insulin in hippocampus and leptin in ileum in the MCSFA group significantly increased, compared with other groups (all Ps < 0.05). Conclusion The high MCSFA diet had the most effect on metabolic disorders in gut-brain axis, but the high n-3 PUFA diet had the least effect on changes in metabolism. |
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institution | Directory Open Access Journal |
issn | 1743-7075 |
language | English |
last_indexed | 2024-04-13T17:10:34Z |
publishDate | 2022-06-01 |
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spelling | doaj.art-0e4462be383e4d6281f9e4d14fd1144d2022-12-22T02:38:17ZengBMCNutrition & Metabolism1743-70752022-06-0119111010.1186/s12986-022-00675-3High-fat diets containing different types of fatty acids modulate gut-brain axis in obese miceYinan Hua0Jingyi Shen1Rong Fan2Rong Xiao3Weiwei Ma4Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical UniversityBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical UniversityBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical UniversityBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical UniversityBeijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical UniversityAbstract Background Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods In our study, normal male C57BL/6J mice were fed to multiple high fatty acid diets (long-chain and medium-chain saturated fatty acid, LCSFA and MCSFA group; n-3 and n-6 polyunsaturated fatty acid, n-3 and n-6 PUFA group; monounsaturated fatty acid, MUFA group; trans fatty acid, TFA group) and a basic diet (control, CON group) for 19 weeks. To investigate the effects of high-fat diets on metabolic responses of gut-brain axis in obese mice, blood lipids were detected by fast gas chromatography, and related proteins in brain and intestine were detected using Western blotting, ELISA, and immunochemistry analysis. Results All high-fat diets regardless of their fatty acid composition induced obesity, lipid disorders, intestinal barrier dysfunction, and changes in gut-brain axis related factors except basal diet in mice. For example, the protein expression of zonula occludens-1 (ZO-1) in ileum in the n-3 PUFA group was higher than that in the MCSFA group (P < 0.05). The expressions of insulin in hippocampus and leptin in ileum in the MCSFA group significantly increased, compared with other groups (all Ps < 0.05). Conclusion The high MCSFA diet had the most effect on metabolic disorders in gut-brain axis, but the high n-3 PUFA diet had the least effect on changes in metabolism.https://doi.org/10.1186/s12986-022-00675-3Fatty acidHigh-fat dietIntestinal barrierGut-brain axisObesity |
spellingShingle | Yinan Hua Jingyi Shen Rong Fan Rong Xiao Weiwei Ma High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice Nutrition & Metabolism Fatty acid High-fat diet Intestinal barrier Gut-brain axis Obesity |
title | High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice |
title_full | High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice |
title_fullStr | High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice |
title_full_unstemmed | High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice |
title_short | High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice |
title_sort | high fat diets containing different types of fatty acids modulate gut brain axis in obese mice |
topic | Fatty acid High-fat diet Intestinal barrier Gut-brain axis Obesity |
url | https://doi.org/10.1186/s12986-022-00675-3 |
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