Cytokine and microbiota profiles in obesity-related hypertension patients
BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hype...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1325261/full |
| _version_ | 1797353436586442752 |
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| author | María Magdalena Aguirre-García Amedeo Amedei Amedeo Amedei Paulina Hernández-Ruiz Ana Pamela Gómez-García Elena Niccolai Aura M. Moreno-Rodríguez Sandra Pinto-Cardoso Adriana Alviter-Plata Alma R. Escalona-Montaño Erick R. Ordaz-Robles María del C. González-Salazar Rashidi Springall Del Villar Enrique A. Berrios-Bárcenas Nydia Ávila-Vanzzini |
| author_facet | María Magdalena Aguirre-García Amedeo Amedei Amedeo Amedei Paulina Hernández-Ruiz Ana Pamela Gómez-García Elena Niccolai Aura M. Moreno-Rodríguez Sandra Pinto-Cardoso Adriana Alviter-Plata Alma R. Escalona-Montaño Erick R. Ordaz-Robles María del C. González-Salazar Rashidi Springall Del Villar Enrique A. Berrios-Bárcenas Nydia Ávila-Vanzzini |
| author_sort | María Magdalena Aguirre-García |
| collection | DOAJ |
| description | BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension. |
| first_indexed | 2024-03-08T13:31:09Z |
| format | Article |
| id | doaj.art-0e47e39b14044e3395fa8306ced3ab9d |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T13:31:09Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-0e47e39b14044e3395fa8306ced3ab9d2024-01-17T08:45:46ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011310.3389/fcimb.2023.13252611325261Cytokine and microbiota profiles in obesity-related hypertension patientsMaría Magdalena Aguirre-García0Amedeo Amedei1Amedeo Amedei2Paulina Hernández-Ruiz3Ana Pamela Gómez-García4Elena Niccolai5Aura M. Moreno-Rodríguez6Sandra Pinto-Cardoso7Adriana Alviter-Plata8Alma R. Escalona-Montaño9Erick R. Ordaz-Robles10María del C. González-Salazar11Rashidi Springall Del Villar12Enrique A. Berrios-Bárcenas13Nydia Ávila-Vanzzini14Unidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyInterdisciplinary Internal Medicine Unit, Careggi University Hospital, Florence, ItalyUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoCentro de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Ciudad de México, MexicoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoOutpatient Clinic, Cardiovascular Risk Factors Clinic, Instituto Nacional de Cardiología "Ignacio Chávez", Ciudad de México, MexicoDepartment of Immunology, Instituto Nacional de Cardiología "Ignacio Chávez", Ciudad de México, MexicoOutpatient Clinic, Cardiovascular Risk Factors Clinic, Instituto Nacional de Cardiología "Ignacio Chávez", Ciudad de México, MexicoUnidad de Investigación UNAM-INC, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Instituto Nacional de Cardiología "Ignacio Chávez, Ciudad de México, MexicoBackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1325261/fullhuman microbiomeoral microbiotagut microbiotaobeseoverweighthigh blood pressure |
| spellingShingle | María Magdalena Aguirre-García Amedeo Amedei Amedeo Amedei Paulina Hernández-Ruiz Ana Pamela Gómez-García Elena Niccolai Aura M. Moreno-Rodríguez Sandra Pinto-Cardoso Adriana Alviter-Plata Alma R. Escalona-Montaño Erick R. Ordaz-Robles María del C. González-Salazar Rashidi Springall Del Villar Enrique A. Berrios-Bárcenas Nydia Ávila-Vanzzini Cytokine and microbiota profiles in obesity-related hypertension patients Frontiers in Cellular and Infection Microbiology human microbiome oral microbiota gut microbiota obese overweight high blood pressure |
| title | Cytokine and microbiota profiles in obesity-related hypertension patients |
| title_full | Cytokine and microbiota profiles in obesity-related hypertension patients |
| title_fullStr | Cytokine and microbiota profiles in obesity-related hypertension patients |
| title_full_unstemmed | Cytokine and microbiota profiles in obesity-related hypertension patients |
| title_short | Cytokine and microbiota profiles in obesity-related hypertension patients |
| title_sort | cytokine and microbiota profiles in obesity related hypertension patients |
| topic | human microbiome oral microbiota gut microbiota obese overweight high blood pressure |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1325261/full |
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