Defining Immunogenic and Radioimmunogenic Tumors
In the cancer literature tumors are inconsistently labeled as ‘immunogenic’, and experimental results are occasionally dismissed since they are only tested in known ‘responsive’ tumor models. The definition of immunogenicity has moved from its classical definition based on the rejection of secondary...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.667075/full |
| _version_ | 1831588931606413312 |
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| author | Terry R. Medler Tiffany C. Blair Tiffany C. Blair Marka R. Crittenden Marka R. Crittenden Marka R. Crittenden Michael J. Gough Michael J. Gough |
| author_facet | Terry R. Medler Tiffany C. Blair Tiffany C. Blair Marka R. Crittenden Marka R. Crittenden Marka R. Crittenden Michael J. Gough Michael J. Gough |
| author_sort | Terry R. Medler |
| collection | DOAJ |
| description | In the cancer literature tumors are inconsistently labeled as ‘immunogenic’, and experimental results are occasionally dismissed since they are only tested in known ‘responsive’ tumor models. The definition of immunogenicity has moved from its classical definition based on the rejection of secondary tumors to a more nebulous definition based on immune infiltrates and response to immunotherapy interventions. This review discusses the basis behind tumor immunogenicity and the variation between tumor models, then moves to discuss how these principles apply to the response to radiation therapy. In this way we can identify radioimmunogenic tumor models that are particularly responsive to immunotherapy only when combined with radiation, and identify the interventions that can convert unresponsive tumors so that they can also respond to these treatments. |
| first_indexed | 2024-12-18T00:33:39Z |
| format | Article |
| id | doaj.art-0e4aca96c80545d69854d5e601af7cbb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-18T00:33:39Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0e4aca96c80545d69854d5e601af7cbb2022-12-21T21:27:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.667075667075Defining Immunogenic and Radioimmunogenic TumorsTerry R. Medler0Tiffany C. Blair1Tiffany C. Blair2Marka R. Crittenden3Marka R. Crittenden4Marka R. Crittenden5Michael J. Gough6Michael J. Gough7Earle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, OR, United StatesEarle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, OR, United StatesMolecular Microbiology and Immunology, OHSU, Portland, OR, United StatesEarle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, OR, United StatesMolecular Microbiology and Immunology, OHSU, Portland, OR, United StatesThe Oregon Clinic, Portland, OR, United StatesEarle A. Chiles Research Institute, Providence Cancer Institute, Providence Portland Medical Center, Portland, OR, United StatesMolecular Microbiology and Immunology, OHSU, Portland, OR, United StatesIn the cancer literature tumors are inconsistently labeled as ‘immunogenic’, and experimental results are occasionally dismissed since they are only tested in known ‘responsive’ tumor models. The definition of immunogenicity has moved from its classical definition based on the rejection of secondary tumors to a more nebulous definition based on immune infiltrates and response to immunotherapy interventions. This review discusses the basis behind tumor immunogenicity and the variation between tumor models, then moves to discuss how these principles apply to the response to radiation therapy. In this way we can identify radioimmunogenic tumor models that are particularly responsive to immunotherapy only when combined with radiation, and identify the interventions that can convert unresponsive tumors so that they can also respond to these treatments.https://www.frontiersin.org/articles/10.3389/fonc.2021.667075/fulltumorT cellimmunogenicradiationdendritic cellpriming |
| spellingShingle | Terry R. Medler Tiffany C. Blair Tiffany C. Blair Marka R. Crittenden Marka R. Crittenden Marka R. Crittenden Michael J. Gough Michael J. Gough Defining Immunogenic and Radioimmunogenic Tumors Frontiers in Oncology tumor T cell immunogenic radiation dendritic cell priming |
| title | Defining Immunogenic and Radioimmunogenic Tumors |
| title_full | Defining Immunogenic and Radioimmunogenic Tumors |
| title_fullStr | Defining Immunogenic and Radioimmunogenic Tumors |
| title_full_unstemmed | Defining Immunogenic and Radioimmunogenic Tumors |
| title_short | Defining Immunogenic and Radioimmunogenic Tumors |
| title_sort | defining immunogenic and radioimmunogenic tumors |
| topic | tumor T cell immunogenic radiation dendritic cell priming |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.667075/full |
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