Psoríase na era dos biológicos.
Chronic plaque psoriasis is an immune-mediated, inflammatory skin disease with a heavy burden on quality of life of patients. Conventional systemic therapies, including cyclosporine, methotrexate, acitretin and photo(chemo)therapy, have proved to be effective, but the risk of toxicity prevents their...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2010-06-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/629 |
| _version_ | 1817980153031032832 |
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| author | Tiago Torres Glória Cunha Velho Madalena Sanches Manuela Selores |
| author_facet | Tiago Torres Glória Cunha Velho Madalena Sanches Manuela Selores |
| author_sort | Tiago Torres |
| collection | DOAJ |
| description | Chronic plaque psoriasis is an immune-mediated, inflammatory skin disease with a heavy burden on quality of life of patients. Conventional systemic therapies, including cyclosporine, methotrexate, acitretin and photo(chemo)therapy, have proved to be effective, but the risk of toxicity prevents their prolonged and continuous use. Advances in the understanding of psoriasis immunopathogenesis have led to the development of drugs, designed to selectively interfere with the immune mechanisms that induce psoriasis, called biologics. These agents have proven to be a convenient, safe and effective alternative to conventional treatments, and have become an important part of the dermatologist therapeutic armamentarium. This review will focus on the mechanisms of action, guidelines for usage, efficacy data and safety concerns of the main biologics used in Europe for the treatment of moderate to severe plaque psoriasis: etanercept, infliximab, adalimumab. Although efalizumab's marketing authorization, approved since 2003, has been suspended recently (February 2009) across the European Union, it will also be briefly discussed. |
| first_indexed | 2024-04-13T22:50:51Z |
| format | Article |
| id | doaj.art-0e4ca46ea3314853aa1ae491ef51f004 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T22:50:51Z |
| publishDate | 2010-06-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-0e4ca46ea3314853aa1ae491ef51f0042022-12-22T02:26:11ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582010-06-0123310.20344/amp.629Psoríase na era dos biológicos.Tiago Torres0Glória Cunha VelhoMadalena SanchesManuela SeloresServiço de Dermatologia, Hospital de Santo António, Porto.Chronic plaque psoriasis is an immune-mediated, inflammatory skin disease with a heavy burden on quality of life of patients. Conventional systemic therapies, including cyclosporine, methotrexate, acitretin and photo(chemo)therapy, have proved to be effective, but the risk of toxicity prevents their prolonged and continuous use. Advances in the understanding of psoriasis immunopathogenesis have led to the development of drugs, designed to selectively interfere with the immune mechanisms that induce psoriasis, called biologics. These agents have proven to be a convenient, safe and effective alternative to conventional treatments, and have become an important part of the dermatologist therapeutic armamentarium. This review will focus on the mechanisms of action, guidelines for usage, efficacy data and safety concerns of the main biologics used in Europe for the treatment of moderate to severe plaque psoriasis: etanercept, infliximab, adalimumab. Although efalizumab's marketing authorization, approved since 2003, has been suspended recently (February 2009) across the European Union, it will also be briefly discussed.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/629 |
| spellingShingle | Tiago Torres Glória Cunha Velho Madalena Sanches Manuela Selores Psoríase na era dos biológicos. Acta Médica Portuguesa |
| title | Psoríase na era dos biológicos. |
| title_full | Psoríase na era dos biológicos. |
| title_fullStr | Psoríase na era dos biológicos. |
| title_full_unstemmed | Psoríase na era dos biológicos. |
| title_short | Psoríase na era dos biológicos. |
| title_sort | psoriase na era dos biologicos |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/629 |
| work_keys_str_mv | AT tiagotorres psoriasenaeradosbiologicos AT gloriacunhavelho psoriasenaeradosbiologicos AT madalenasanches psoriasenaeradosbiologicos AT manuelaselores psoriasenaeradosbiologicos |