Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study
Abstract Background The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study. Methods This prospective cohort study included 772...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1307-0 |
| _version_ | 1819052060898754560 |
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| author | Gwang Sil Kim Hyun Ho Oh Sang Hyun Kim Byung Ok Kim Young Sup Byun |
| author_facet | Gwang Sil Kim Hyun Ho Oh Sang Hyun Kim Byung Ok Kim Young Sup Byun |
| author_sort | Gwang Sil Kim |
| collection | DOAJ |
| description | Abstract Background The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study. Methods This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1C level. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2. We assessed the predictive value of prediabetes for the incidence of CKD, and investigated the incidence of cardiovascular disease including coronary artery disease and stroke. Results Over a median follow-up period of 8.7 years, 871 of 7728 (11.3%) subjects developed incident CKD. Patients with prediabetes, as defined by IGT or HbA1C, developed incident CKD more frequently than the non-prediabetic group did. The risk of CKD development at follow-up was analyzed according to different prediabetes definitions. Compared with the non-prediabetic group, the IGT- (Hazard ratio [HR] = 1.135, 95% confidence interval [CI] = 1.182–1.310, P = 0.043) and HbA1C-defined prediabetic groups (HR = 1.391, 95% CI = 1.213–1.595, P < 0.001) were significantly associated with incident CKD after adjusting for traditional CKD risk factors; however, IFG was not associated with incident CKD. Conclusion IGT- or HbA1C-defined prediabetes is an independent predictor of incident CKD. The measurement of these parameters might enable early detection of CKD risk, allowing physicians to initiate preventive measures and improve patient outcomes. |
| first_indexed | 2024-12-21T12:13:50Z |
| format | Article |
| id | doaj.art-0e4fd2336a124893a98cc986f72b575f |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T12:13:50Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-0e4fd2336a124893a98cc986f72b575f2022-12-21T19:04:30ZengBMCBMC Nephrology1471-23692019-04-012011610.1186/s12882-019-1307-0Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort studyGwang Sil Kim0Hyun Ho Oh1Sang Hyun Kim2Byung Ok Kim3Young Sup Byun4Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje UniversityDivision of Nephrology, Department of Internal Medicine, Sanggye Paik Hospital, Inje UniversityDivision of Nephrology, Department of Internal Medicine, Sanggye Paik Hospital, Inje UniversityDivision of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje UniversityDivision of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje UniversityAbstract Background The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study. Methods This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1C level. CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2. We assessed the predictive value of prediabetes for the incidence of CKD, and investigated the incidence of cardiovascular disease including coronary artery disease and stroke. Results Over a median follow-up period of 8.7 years, 871 of 7728 (11.3%) subjects developed incident CKD. Patients with prediabetes, as defined by IGT or HbA1C, developed incident CKD more frequently than the non-prediabetic group did. The risk of CKD development at follow-up was analyzed according to different prediabetes definitions. Compared with the non-prediabetic group, the IGT- (Hazard ratio [HR] = 1.135, 95% confidence interval [CI] = 1.182–1.310, P = 0.043) and HbA1C-defined prediabetic groups (HR = 1.391, 95% CI = 1.213–1.595, P < 0.001) were significantly associated with incident CKD after adjusting for traditional CKD risk factors; however, IFG was not associated with incident CKD. Conclusion IGT- or HbA1C-defined prediabetes is an independent predictor of incident CKD. The measurement of these parameters might enable early detection of CKD risk, allowing physicians to initiate preventive measures and improve patient outcomes.http://link.springer.com/article/10.1186/s12882-019-1307-0PrediabetesChronic kidney diseaseCardiovascular diseaseGeneral population |
| spellingShingle | Gwang Sil Kim Hyun Ho Oh Sang Hyun Kim Byung Ok Kim Young Sup Byun Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study BMC Nephrology Prediabetes Chronic kidney disease Cardiovascular disease General population |
| title | Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study |
| title_full | Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study |
| title_fullStr | Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study |
| title_full_unstemmed | Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study |
| title_short | Association between prediabetes (defined by HbA1C, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study |
| title_sort | association between prediabetes defined by hba1c fasting plasma glucose and impaired glucose tolerance and the development of chronic kidney disease a 9 year prospective cohort study |
| topic | Prediabetes Chronic kidney disease Cardiovascular disease General population |
| url | http://link.springer.com/article/10.1186/s12882-019-1307-0 |
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