Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s disease

Abstract Many of the Alzheimer’s disease (AD) risk genes are specifically expressed in microglia and astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD pathophysiology remains unclear. Here, we derive cell-type-specific AD polygenic risk scores (ADPRS) fro...

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Bibliographic Details
Main Authors: Hyun-Sik Yang, Ling Teng, Daniel Kang, Vilas Menon, Tian Ge, Hilary K. Finucane, Aaron P. Schultz, Michael Properzi, Hans-Ulrich Klein, Lori B. Chibnik, Julie A. Schneider, David A. Bennett, Timothy J. Hohman, Richard P. Mayeux, Keith A. Johnson, Philip L. De Jager, Reisa A. Sperling
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43132-2

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