Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
<i>Background:</i> Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition associated with several negative health outcomes. A hallmark of ME/CFS is decreased exercise capacity and often profound exercise intolerance. The causes of ME/CSF and its related s...
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MDPI AG
2020-10-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/8/4/406 |
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| author | Per Ole Iversen Thomas Gero von Lueder Kristin Reimers Kardel Katarina Lien |
| author_facet | Per Ole Iversen Thomas Gero von Lueder Kristin Reimers Kardel Katarina Lien |
| author_sort | Per Ole Iversen |
| collection | DOAJ |
| description | <i>Background:</i> Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition associated with several negative health outcomes. A hallmark of ME/CFS is decreased exercise capacity and often profound exercise intolerance. The causes of ME/CSF and its related symptoms are unknown, but there are indications of a dysregulated metabolism with impaired glycolytic vs oxidative energy balance. In line with this, we recently demonstrated abnormal lactate accumulation among ME/CFS patients compared with healthy controls after exercise testing. Here we examined if cardiac dimensions and function were altered in ME/CFS, as this could lead to increased lactate production. <i>Methods:</i> We studied 16 female ME/CFS patients and 10 healthy controls with supine transthoracic echocardiography, and we assessed cardiac dimensions and function by conventional echocardiographic and Doppler analysis as well as novel tissue Doppler and strain variables. <i>Results:</i> A detailed analyses of key variables of cardiac dimensions and cardiac function revealed no significant differences between the two study groups. <i>Conclusion:</i> In this cohort of well-described ME/CFS patients, we found no significant differences in echocardiographic variables characterizing cardiac dimensions and function compared with healthy controls. |
| first_indexed | 2024-03-10T15:33:09Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T15:33:09Z |
| publishDate | 2020-10-01 |
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| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-0e5300794f8e4b0685be8ebf4452b80e2023-11-20T17:24:18ZengMDPI AGHealthcare2227-90322020-10-018440610.3390/healthcare8040406Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue SyndromePer Ole Iversen0Thomas Gero von Lueder1Kristin Reimers Kardel2Katarina Lien3Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, NorwayDepartment of Cardiology, Oslo University Hospital, 0424 Oslo, NorwayDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, NorwayDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway<i>Background:</i> Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition associated with several negative health outcomes. A hallmark of ME/CFS is decreased exercise capacity and often profound exercise intolerance. The causes of ME/CSF and its related symptoms are unknown, but there are indications of a dysregulated metabolism with impaired glycolytic vs oxidative energy balance. In line with this, we recently demonstrated abnormal lactate accumulation among ME/CFS patients compared with healthy controls after exercise testing. Here we examined if cardiac dimensions and function were altered in ME/CFS, as this could lead to increased lactate production. <i>Methods:</i> We studied 16 female ME/CFS patients and 10 healthy controls with supine transthoracic echocardiography, and we assessed cardiac dimensions and function by conventional echocardiographic and Doppler analysis as well as novel tissue Doppler and strain variables. <i>Results:</i> A detailed analyses of key variables of cardiac dimensions and cardiac function revealed no significant differences between the two study groups. <i>Conclusion:</i> In this cohort of well-described ME/CFS patients, we found no significant differences in echocardiographic variables characterizing cardiac dimensions and function compared with healthy controls.https://www.mdpi.com/2227-9032/8/4/406cardiac functionechocardiographymyalgic encephalomyelitis/chronic fatigue syndrome |
| spellingShingle | Per Ole Iversen Thomas Gero von Lueder Kristin Reimers Kardel Katarina Lien Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Healthcare cardiac function echocardiography myalgic encephalomyelitis/chronic fatigue syndrome |
| title | Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_full | Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_fullStr | Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_full_unstemmed | Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_short | Cardiac Dimensions and Function are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome |
| title_sort | cardiac dimensions and function are not altered among females with the myalgic encephalomyelitis chronic fatigue syndrome |
| topic | cardiac function echocardiography myalgic encephalomyelitis/chronic fatigue syndrome |
| url | https://www.mdpi.com/2227-9032/8/4/406 |
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