Review of role of fatty acid binding protein-4 in obesity-associated tumors
Obesity is one of the major factors threatening human health. Excessive fat accumulation not only has detrimental effects on human metabolism and cardiovascular system, but also is highly correlated to the incidence and mortality of various tumors. Fatty acid binding protein-4 (FABP4) is a small mol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-10-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-10-1311.shtml |
| _version_ | 1797303976109015040 |
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| author | WU Ruifang FENG Ming MENG Jian |
| author_facet | WU Ruifang FENG Ming MENG Jian |
| author_sort | WU Ruifang |
| collection | DOAJ |
| description | Obesity is one of the major factors threatening human health. Excessive fat accumulation not only has detrimental effects on human metabolism and cardiovascular system, but also is highly correlated to the incidence and mortality of various tumors. Fatty acid binding protein-4 (FABP4) is a small molecule protein mainly expressed in adipocytes and macrophages, and is responsible for participating in fatty acid transport and lipid response. It has been found that FABP4 levels are not only associated with body fat content, but also aberrantly expressed in various obesity-associated tumor cells and tumor microenvironment, which is closely related to obesity-associated carcinogenesis, metastasis, recurrence and patient prognosis. Since FABP4 expression varies in different types of obesity-associated tumors, suggesting a complex role of FABP4 in tumorigenesis. Based on this, this article reviews different roles of FABP4 in multiple obesity-associated tumors. |
| first_indexed | 2024-03-08T00:01:23Z |
| format | Article |
| id | doaj.art-0e55ba3d26f64d61b7b4ad287578e5ba |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T00:01:23Z |
| publishDate | 2023-10-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-0e55ba3d26f64d61b7b4ad287578e5ba2024-02-18T02:27:29ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-10-0143101311131610.3969/j.issn.1674-8115.2023.10.0131674-8115（2023）10-1311-06Review of role of fatty acid binding protein-4 in obesity-associated tumorsWU RuifangFENG MingMENG JianObesity is one of the major factors threatening human health. Excessive fat accumulation not only has detrimental effects on human metabolism and cardiovascular system, but also is highly correlated to the incidence and mortality of various tumors. Fatty acid binding protein-4 (FABP4) is a small molecule protein mainly expressed in adipocytes and macrophages, and is responsible for participating in fatty acid transport and lipid response. It has been found that FABP4 levels are not only associated with body fat content, but also aberrantly expressed in various obesity-associated tumor cells and tumor microenvironment, which is closely related to obesity-associated carcinogenesis, metastasis, recurrence and patient prognosis. Since FABP4 expression varies in different types of obesity-associated tumors, suggesting a complex role of FABP4 in tumorigenesis. Based on this, this article reviews different roles of FABP4 in multiple obesity-associated tumors.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-10-1311.shtmlfatty acid binding protein-4 (fabp4)obesity-associated tumoradipocyteadipocytokinetumor microenvironment |
| spellingShingle | WU Ruifang FENG Ming MENG Jian Review of role of fatty acid binding protein-4 in obesity-associated tumors Shanghai Jiaotong Daxue xuebao. Yixue ban fatty acid binding protein-4 (fabp4) obesity-associated tumor adipocyte adipocytokine tumor microenvironment |
| title | Review of role of fatty acid binding protein-4 in obesity-associated tumors |
| title_full | Review of role of fatty acid binding protein-4 in obesity-associated tumors |
| title_fullStr | Review of role of fatty acid binding protein-4 in obesity-associated tumors |
| title_full_unstemmed | Review of role of fatty acid binding protein-4 in obesity-associated tumors |
| title_short | Review of role of fatty acid binding protein-4 in obesity-associated tumors |
| title_sort | review of role of fatty acid binding protein 4 in obesity associated tumors |
| topic | fatty acid binding protein-4 (fabp4) obesity-associated tumor adipocyte adipocytokine tumor microenvironment |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-10-1311.shtml |
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