Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients
Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of...
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.678594/full |
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| author | Yong-Mei Wang Yong-Mei Wang Ya-Yun Xu Yi Zhai Yi Zhai Yi Zhai Qian-Qian Wu Qian-Qian Wu Qian-Qian Wu Wen Huang Wen Huang Wen Huang Yan Liang Yan Liang Yan Liang Yan-Hong Sun Yan-Hong Sun Lian-Yin Xu Lian-Yin Xu |
| author_facet | Yong-Mei Wang Yong-Mei Wang Ya-Yun Xu Yi Zhai Yi Zhai Yi Zhai Qian-Qian Wu Qian-Qian Wu Qian-Qian Wu Wen Huang Wen Huang Wen Huang Yan Liang Yan Liang Yan Liang Yan-Hong Sun Yan-Hong Sun Lian-Yin Xu Lian-Yin Xu |
| author_sort | Yong-Mei Wang |
| collection | DOAJ |
| description | Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. The patients in the treatment group were treated with taVNS of the bilateral auricular concha using an ear vagus nerve stimulator. The Pennsylvania Alcohol Craving Scale was used to evaluate the extent of craving for alcohol. The Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS) were used to evaluate the extent of anxiety and depression symptoms, respectively. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Enzyme-linked immunosorbent assay was used to measure plasma BDNF, IL-6, TNF-α, and leptin levels. The results showed that the SDS and PSQI scores were significantly lower in the treatment group than in the control group. Moreover, compared with the control group, the average BDNF levels in the treatment group were significantly increased. These results suggest that taVNS could improve the depression symptoms and sleep quality in alcohol-dependent patients after withdrawal, which might be related to the upregulation of plasma BDNF levels. |
| first_indexed | 2024-12-16T08:25:25Z |
| format | Article |
| id | doaj.art-0e58339f61cd4d059e8288f085dfdb20 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-16T08:25:25Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-0e58339f61cd4d059e8288f085dfdb202022-12-21T22:38:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-08-011210.3389/fpsyt.2021.678594678594Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent PatientsYong-Mei Wang0Yong-Mei Wang1Ya-Yun Xu2Yi Zhai3Yi Zhai4Yi Zhai5Qian-Qian Wu6Qian-Qian Wu7Qian-Qian Wu8Wen Huang9Wen Huang10Wen Huang11Yan Liang12Yan Liang13Yan Liang14Yan-Hong Sun15Yan-Hong Sun16Lian-Yin Xu17Lian-Yin Xu18Department of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Material Dependence, Hefei Fourth People's Hospital, Hefei, ChinaHefei Medical Research Centre on Alcohol Addiction, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Material Dependence, Hefei Fourth People's Hospital, Hefei, ChinaHefei Medical Research Centre on Alcohol Addiction, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Material Dependence, Hefei Fourth People's Hospital, Hefei, ChinaHefei Medical Research Centre on Alcohol Addiction, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Material Dependence, Hefei Fourth People's Hospital, Hefei, ChinaHefei Medical Research Centre on Alcohol Addiction, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Pharmacy, Hefei Fourth People's Hospital, Hefei, ChinaDepartment of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaProtracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. The patients in the treatment group were treated with taVNS of the bilateral auricular concha using an ear vagus nerve stimulator. The Pennsylvania Alcohol Craving Scale was used to evaluate the extent of craving for alcohol. The Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS) were used to evaluate the extent of anxiety and depression symptoms, respectively. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Enzyme-linked immunosorbent assay was used to measure plasma BDNF, IL-6, TNF-α, and leptin levels. The results showed that the SDS and PSQI scores were significantly lower in the treatment group than in the control group. Moreover, compared with the control group, the average BDNF levels in the treatment group were significantly increased. These results suggest that taVNS could improve the depression symptoms and sleep quality in alcohol-dependent patients after withdrawal, which might be related to the upregulation of plasma BDNF levels.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.678594/fullalcohol dependencebrain-derived neurotrophic factordepressionprotracted alcohol withdrawal symptomssleep qualitytranscutaneous auricular vagus nerve stimulation |
| spellingShingle | Yong-Mei Wang Yong-Mei Wang Ya-Yun Xu Yi Zhai Yi Zhai Yi Zhai Qian-Qian Wu Qian-Qian Wu Qian-Qian Wu Wen Huang Wen Huang Wen Huang Yan Liang Yan Liang Yan Liang Yan-Hong Sun Yan-Hong Sun Lian-Yin Xu Lian-Yin Xu Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients Frontiers in Psychiatry alcohol dependence brain-derived neurotrophic factor depression protracted alcohol withdrawal symptoms sleep quality transcutaneous auricular vagus nerve stimulation |
| title | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients |
| title_full | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients |
| title_fullStr | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients |
| title_full_unstemmed | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients |
| title_short | Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients |
| title_sort | effect of transcutaneous auricular vagus nerve stimulation on protracted alcohol withdrawal symptoms in male alcohol dependent patients |
| topic | alcohol dependence brain-derived neurotrophic factor depression protracted alcohol withdrawal symptoms sleep quality transcutaneous auricular vagus nerve stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.678594/full |
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