Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

Abstract The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine such variable outcomes remain unresolved. In this study, we identified immunodominant CD8 T-cell epitopes in the spik...

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Bibliographic Details
Main Authors: Swapnil Mahajan, Vasumathi Kode, Keshav Bhojak, Coral Karunakaran, Kayla Lee, Malini Manoharan, Athulya Ramesh, Sudheendra HV, Ankita Srivastava, Rekha Sathian, Tahira Khan, Prasanna Kumar, Ravi Gupta, Papia Chakraborty, Amitabha Chaudhuri
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92521-4

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