Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington’s Disease Models

Transcriptional and Histone Acetylation Changes Associated with CRE Elements Expose Key Factors Governing the Regulatory Circuit in the Early Stage of Huntington’s Disease Models

Huntington’s disease (HD) is a disorder caused by an abnormal expansion of trinucleotide CAG repeats within the huntingtin (Htt) gene. Under normal conditions, the CREB Binding Protein interacts with CREB elements and acetylates Lysine 27 of Histone 3 to direct the expression of several genes. Howev...

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Bibliographic Details
Main Authors: Sandra Arancibia-Opazo, J. Sebastián Contreras-Riquelme, Mario Sánchez, Marisol Cisternas-Olmedo, René L. Vidal, Alberto J. M. Martin, Mauricio A. Sáez
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
Huntington’s disease
histone acetylation
polyQ diseases
cAMP response element-binding protein
gene regulatory networks
Online Access:https://www.mdpi.com/1422-0067/24/13/10848

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