Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents
A universal vaccination program among preadolescents was implemented in Catalonia, Spain, during the period of 1999–2013 and its effectiveness has been clearly demonstrated by an overall significant attack rate reduction. However, reductions were not constant over time, and increases were again obse...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/16/4/6842 |
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| author | Lucía D’Andrea Francisco J. Pérez-Rodríguez Montserrat de Castellarnau Sandra Manzanares Josep Lite Susana Guix Albert Bosch Rosa M. Pintó |
| author_facet | Lucía D’Andrea Francisco J. Pérez-Rodríguez Montserrat de Castellarnau Sandra Manzanares Josep Lite Susana Guix Albert Bosch Rosa M. Pintó |
| author_sort | Lucía D’Andrea |
| collection | DOAJ |
| description | A universal vaccination program among preadolescents was implemented in Catalonia, Spain, during the period of 1999–2013 and its effectiveness has been clearly demonstrated by an overall significant attack rate reduction. However, reductions were not constant over time, and increases were again observed in 2002–2009 due to the occurrence of huge outbreaks. In the following years, in the absence of large outbreaks, the attack rate decreased again to very low levels. However, an increase of symptomatic cases in the <5 age group has recently been observed. This is an unexpected observation since children younger than 6 are mostly asymptomatic. Such a long vaccination campaign offers the opportunity to analyze not only the effectiveness of vaccination, but also the influence of the circulating genotypes on the incidence of hepatitis A among the different age groups. This study has revealed the emergence of genotype IC during a foodborne outbreak, the short-lived circulation of vaccine-escape variants isolated during an outbreak among the men-having-sex-with-men group, and the association of genotype IIIA with the increase of symptomatic cases among the very young. From a public health perspective, two conclusions may be drawn: vaccination is better at an early age, and the vaccination schedule must be complete and include all recommended vaccine doses. |
| first_indexed | 2024-04-12T10:15:30Z |
| format | Article |
| id | doaj.art-0e5d22a3655942e997fe236b5c4d080a |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T10:15:30Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0e5d22a3655942e997fe236b5c4d080a2022-12-22T03:37:13ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-03-011646842685410.3390/ijms16046842ijms16046842Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of PreadolescentsLucía D’Andrea0Francisco J. Pérez-Rodríguez1Montserrat de Castellarnau2Sandra Manzanares3Josep Lite4Susana Guix5Albert Bosch6Rosa M. Pintó7Enteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainEnteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainEnteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainPublic Health Agency of Barcelona, Plaça Lesseps 1, 08023 Barcelona, SpainMicrobiology Unit, CatLab, 08232 Viladecavalls, SpainEnteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainEnteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainEnteric Virus Laboratory, Department of Microbiology and Institute of Nutrition and Food Safety, University of Barcelona, Diagonal 643, 08028 Barcelona, SpainA universal vaccination program among preadolescents was implemented in Catalonia, Spain, during the period of 1999–2013 and its effectiveness has been clearly demonstrated by an overall significant attack rate reduction. However, reductions were not constant over time, and increases were again observed in 2002–2009 due to the occurrence of huge outbreaks. In the following years, in the absence of large outbreaks, the attack rate decreased again to very low levels. However, an increase of symptomatic cases in the <5 age group has recently been observed. This is an unexpected observation since children younger than 6 are mostly asymptomatic. Such a long vaccination campaign offers the opportunity to analyze not only the effectiveness of vaccination, but also the influence of the circulating genotypes on the incidence of hepatitis A among the different age groups. This study has revealed the emergence of genotype IC during a foodborne outbreak, the short-lived circulation of vaccine-escape variants isolated during an outbreak among the men-having-sex-with-men group, and the association of genotype IIIA with the increase of symptomatic cases among the very young. From a public health perspective, two conclusions may be drawn: vaccination is better at an early age, and the vaccination schedule must be complete and include all recommended vaccine doses.http://www.mdpi.com/1422-0067/16/4/6842hepatitis AHAV genotypesage-groupchildrenMSMvaccine-escape variantsvaccination |
| spellingShingle | Lucía D’Andrea Francisco J. Pérez-Rodríguez Montserrat de Castellarnau Sandra Manzanares Josep Lite Susana Guix Albert Bosch Rosa M. Pintó Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents International Journal of Molecular Sciences hepatitis A HAV genotypes age-group children MSM vaccine-escape variants vaccination |
| title | Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents |
| title_full | Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents |
| title_fullStr | Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents |
| title_full_unstemmed | Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents |
| title_short | Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents |
| title_sort | hepatitis a virus genotype distribution during a decade of universal vaccination of preadolescents |
| topic | hepatitis A HAV genotypes age-group children MSM vaccine-escape variants vaccination |
| url | http://www.mdpi.com/1422-0067/16/4/6842 |
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