The Effects of Homocysteine Level in the Critically Ill Patient. A Review
Increased levels of homocysteine (HCYS) represent a risk factor for a series of physiopathological conditions: mental retardation, cardiovascular and neurodegenerative diseases, Parkinson's and Alzheimer's disease, depression, osteoporosis, endothelial dysfunction and inhibition of cell pr...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-09-01
|
| Series: | Journal of Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/jim-2016-0025 |
| _version_ | 1818720599082532864 |
|---|---|
| author | Bedreag Ovidiu Horea Rogobete Alexandru Florin Sandesc Dorel Cradigati Carmen Alina Sarandan Mirela Nartita Radu Dumache Raluca Diaconu Mihai Mircea Papurica Marius |
| author_facet | Bedreag Ovidiu Horea Rogobete Alexandru Florin Sandesc Dorel Cradigati Carmen Alina Sarandan Mirela Nartita Radu Dumache Raluca Diaconu Mihai Mircea Papurica Marius |
| author_sort | Bedreag Ovidiu Horea |
| collection | DOAJ |
| description | Increased levels of homocysteine (HCYS) represent a risk factor for a series of physiopathological conditions: mental retardation, cardiovascular and neurodegenerative diseases, Parkinson's and Alzheimer's disease, depression, osteoporosis, endothelial dysfunction and inhibition of cell proliferation. This paper aims to present the pathophysiological implications of HCYS and the correlation of hyperhomocysteinemia (H-HCYS) with critical condition in the intensive care unit (ICU). Hypovitaminosis B and folate deficiency is directly involved in the inhibition of HCYS metabolism and the accumulation of HCYS in the plasma and tissues. Critically ill patients are more prone to H-HCYS due to hypermetabolism and accelerated synthesis produced by reactive oxygen species (ROS). In conclusion it can be affirmed that the determination and monitoring of HCYS plasma levels may be of interest in optimizing the therapy for critically ill patients. Moreover, by controlling HCYS levels, and implicitly the essential cofactors that intervene in the specific biochemical pathways, such as vitamin B6, vitamin B12 and folic acid can provide a diversified and personalized treatment for each patient. |
| first_indexed | 2024-12-17T20:25:24Z |
| format | Article |
| id | doaj.art-0e5d4e70a1ec41e1a860177083cc40f7 |
| institution | Directory Open Access Journal |
| issn | 2501-8132 |
| language | English |
| last_indexed | 2024-12-17T20:25:24Z |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Interdisciplinary Medicine |
| spelling | doaj.art-0e5d4e70a1ec41e1a860177083cc40f72022-12-21T21:33:49ZengSciendoJournal of Interdisciplinary Medicine2501-81322016-09-011213113610.1515/jim-2016-0025jim-2016-0025The Effects of Homocysteine Level in the Critically Ill Patient. A ReviewBedreag Ovidiu Horea0Rogobete Alexandru Florin1Sandesc Dorel2Cradigati Carmen Alina3Sarandan Mirela4Nartita Radu5Dumache Raluca6Diaconu Mihai Mircea7Papurica Marius8 Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, Romania Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, Romania Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, Romania “Casa Austria” Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, Romania “Casa Austria” Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, Romania Faculty of Chemistry, Biology and Geography, West University of Timișoara, Romania Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania Faculty of Medicine, “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania Clinic of Anesthesia and Intensive Care, “Pius Brinzeu” County Emergency Hospital, Timișoara, RomaniaIncreased levels of homocysteine (HCYS) represent a risk factor for a series of physiopathological conditions: mental retardation, cardiovascular and neurodegenerative diseases, Parkinson's and Alzheimer's disease, depression, osteoporosis, endothelial dysfunction and inhibition of cell proliferation. This paper aims to present the pathophysiological implications of HCYS and the correlation of hyperhomocysteinemia (H-HCYS) with critical condition in the intensive care unit (ICU). Hypovitaminosis B and folate deficiency is directly involved in the inhibition of HCYS metabolism and the accumulation of HCYS in the plasma and tissues. Critically ill patients are more prone to H-HCYS due to hypermetabolism and accelerated synthesis produced by reactive oxygen species (ROS). In conclusion it can be affirmed that the determination and monitoring of HCYS plasma levels may be of interest in optimizing the therapy for critically ill patients. Moreover, by controlling HCYS levels, and implicitly the essential cofactors that intervene in the specific biochemical pathways, such as vitamin B6, vitamin B12 and folic acid can provide a diversified and personalized treatment for each patient.https://doi.org/10.1515/jim-2016-0025homocysteinehypovitaminosisoxidative stressintensive care unit |
| spellingShingle | Bedreag Ovidiu Horea Rogobete Alexandru Florin Sandesc Dorel Cradigati Carmen Alina Sarandan Mirela Nartita Radu Dumache Raluca Diaconu Mihai Mircea Papurica Marius The Effects of Homocysteine Level in the Critically Ill Patient. A Review Journal of Interdisciplinary Medicine homocysteine hypovitaminosis oxidative stress intensive care unit |
| title | The Effects of Homocysteine Level in the Critically Ill Patient. A Review |
| title_full | The Effects of Homocysteine Level in the Critically Ill Patient. A Review |
| title_fullStr | The Effects of Homocysteine Level in the Critically Ill Patient. A Review |
| title_full_unstemmed | The Effects of Homocysteine Level in the Critically Ill Patient. A Review |
| title_short | The Effects of Homocysteine Level in the Critically Ill Patient. A Review |
| title_sort | effects of homocysteine level in the critically ill patient a review |
| topic | homocysteine hypovitaminosis oxidative stress intensive care unit |
| url | https://doi.org/10.1515/jim-2016-0025 |
| work_keys_str_mv | AT bedreagovidiuhorea theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT rogobetealexandruflorin theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT sandescdorel theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT cradigaticarmenalina theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT sarandanmirela theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT nartitaradu theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT dumacheraluca theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT diaconumihaimircea theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT papuricamarius theeffectsofhomocysteinelevelinthecriticallyillpatientareview AT bedreagovidiuhorea effectsofhomocysteinelevelinthecriticallyillpatientareview AT rogobetealexandruflorin effectsofhomocysteinelevelinthecriticallyillpatientareview AT sandescdorel effectsofhomocysteinelevelinthecriticallyillpatientareview AT cradigaticarmenalina effectsofhomocysteinelevelinthecriticallyillpatientareview AT sarandanmirela effectsofhomocysteinelevelinthecriticallyillpatientareview AT nartitaradu effectsofhomocysteinelevelinthecriticallyillpatientareview AT dumacheraluca effectsofhomocysteinelevelinthecriticallyillpatientareview AT diaconumihaimircea effectsofhomocysteinelevelinthecriticallyillpatientareview AT papuricamarius effectsofhomocysteinelevelinthecriticallyillpatientareview |