Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan
Abstract Background Dengue fever, caused by dengue virus (DENV), has become one of the most important mosquito-borne viral diseases with a steady rise in global incidence, including the Sudan. Sporadic cases and frequent acute febrile illness outbreaks, compatible with Dengue fever, have been report...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-07-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12889-018-5853-3 |
| _version_ | 1817978376575516672 |
|---|---|
| author | Mawahib H. Eldigail Gamal K. Adam Rabie A. Babiker Fatima Khalid Ibrahim A. Adam Osama H. Omer Mohamed E. Ahmed Sara L. Birair Eltahir M. Haroun Hassan AbuAisha Abdelrahim E. Karrar Hamid S. Abdalla Imadeldin E. Aradaib |
| author_facet | Mawahib H. Eldigail Gamal K. Adam Rabie A. Babiker Fatima Khalid Ibrahim A. Adam Osama H. Omer Mohamed E. Ahmed Sara L. Birair Eltahir M. Haroun Hassan AbuAisha Abdelrahim E. Karrar Hamid S. Abdalla Imadeldin E. Aradaib |
| author_sort | Mawahib H. Eldigail |
| collection | DOAJ |
| description | Abstract Background Dengue fever, caused by dengue virus (DENV), has become one of the most important mosquito-borne viral diseases with a steady rise in global incidence, including the Sudan. Sporadic cases and frequent acute febrile illness outbreaks, compatible with Dengue fever, have been reported in El-Gadarif State, Sudan. However, diagnosis was based almost exclusively on clinical signs without confirmatory laboratory investigations. Despite the magnitude of the problem in El-Gadarif State, no information is currently available with regard to the epidemiology of the disease in this State. El-Gadarif State is one of the largest commercial centers in the Sudan. The objective of the present investigation is to estimate the prevalence of DENV antibodies, and determine the potential risk factors associated with seropositivity among residents of El-Gadarif State. Methods A cross sectional study was conducted in a total of 701residents randomly selected from all 10 localities in El-Gadarif State. The sera from the 701 residents were tested for the presence of DENV-specific immunoglobulin G (IgG) antibodies using a commercially available Anti-dengue IgG enzyme-linked immunosorbent assay (ELISA). Results Among the 701 residents, 334 residents (47.6%) were seropositive for DENV. Mosquito control (OR = 2.73, CI = 1.37–5.87, p-value = 0.001); low income (OR = 2.31, CI: 1.71–6.36, p value = 0.032); sleeping out-doors (OR = 3.73, CI = 2.63–6.23, p-value = 0.013), and localities were determined as potential risk factors for contracting DENV infection. Conclusions The prevalence rate of DENV antibodies among residents of El-Gadarif State is significantly high (47.6%). Further epidemiologic studies including, distribution of mosquito vectors and implementation of improved surveillance are urgently warranted for better prediction and prevention of a possible DENV outbreak in El-Gadarif State, Sudan. |
| first_indexed | 2024-04-13T22:29:19Z |
| format | Article |
| id | doaj.art-0e60ce8faf5c43a4b0e3580005948eb4 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-13T22:29:19Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-0e60ce8faf5c43a4b0e3580005948eb42022-12-22T02:26:59ZengBMCBMC Public Health1471-24582018-07-011811810.1186/s12889-018-5853-3Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, SudanMawahib H. Eldigail0Gamal K. Adam1Rabie A. Babiker2Fatima Khalid3Ibrahim A. Adam4Osama H. Omer5Mohamed E. Ahmed6Sara L. Birair7Eltahir M. Haroun8Hassan AbuAisha9Abdelrahim E. Karrar10Hamid S. Abdalla11Imadeldin E. Aradaib12Molecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumDepartment of Medical laboratory Sciences, Faculty of Medicine, University of ElgadarifDepartment of Medical laboratory Sciences, Faculty of Medicine, University of ElgadarifDepartment of Microbiology, Faculty of Science, University of KassalaMolecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumMolecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumDeanship of Scientific research, Alneelain UniversityDeanship of Scientific research, Alneelain UniversityDeanship of Scientific research, International University of AfricaDeanship of Scientific research, International University of AfricaMolecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumMolecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumMolecular Biology Laboratory (MBL), Department of Clinical Medicine, Faculty of Veterinary Medicine, University of KhartoumAbstract Background Dengue fever, caused by dengue virus (DENV), has become one of the most important mosquito-borne viral diseases with a steady rise in global incidence, including the Sudan. Sporadic cases and frequent acute febrile illness outbreaks, compatible with Dengue fever, have been reported in El-Gadarif State, Sudan. However, diagnosis was based almost exclusively on clinical signs without confirmatory laboratory investigations. Despite the magnitude of the problem in El-Gadarif State, no information is currently available with regard to the epidemiology of the disease in this State. El-Gadarif State is one of the largest commercial centers in the Sudan. The objective of the present investigation is to estimate the prevalence of DENV antibodies, and determine the potential risk factors associated with seropositivity among residents of El-Gadarif State. Methods A cross sectional study was conducted in a total of 701residents randomly selected from all 10 localities in El-Gadarif State. The sera from the 701 residents were tested for the presence of DENV-specific immunoglobulin G (IgG) antibodies using a commercially available Anti-dengue IgG enzyme-linked immunosorbent assay (ELISA). Results Among the 701 residents, 334 residents (47.6%) were seropositive for DENV. Mosquito control (OR = 2.73, CI = 1.37–5.87, p-value = 0.001); low income (OR = 2.31, CI: 1.71–6.36, p value = 0.032); sleeping out-doors (OR = 3.73, CI = 2.63–6.23, p-value = 0.013), and localities were determined as potential risk factors for contracting DENV infection. Conclusions The prevalence rate of DENV antibodies among residents of El-Gadarif State is significantly high (47.6%). Further epidemiologic studies including, distribution of mosquito vectors and implementation of improved surveillance are urgently warranted for better prediction and prevention of a possible DENV outbreak in El-Gadarif State, Sudan.http://link.springer.com/article/10.1186/s12889-018-5853-3EpidemiologySurveyDengue feverELISASudan |
| spellingShingle | Mawahib H. Eldigail Gamal K. Adam Rabie A. Babiker Fatima Khalid Ibrahim A. Adam Osama H. Omer Mohamed E. Ahmed Sara L. Birair Eltahir M. Haroun Hassan AbuAisha Abdelrahim E. Karrar Hamid S. Abdalla Imadeldin E. Aradaib Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan BMC Public Health Epidemiology Survey Dengue fever ELISA Sudan |
| title | Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan |
| title_full | Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan |
| title_fullStr | Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan |
| title_full_unstemmed | Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan |
| title_short | Prevalence of dengue fever virus antibodies and associated risk factors among residents of El-Gadarif state, Sudan |
| title_sort | prevalence of dengue fever virus antibodies and associated risk factors among residents of el gadarif state sudan |
| topic | Epidemiology Survey Dengue fever ELISA Sudan |
| url | http://link.springer.com/article/10.1186/s12889-018-5853-3 |
| work_keys_str_mv | AT mawahibheldigail prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT gamalkadam prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT rabieababiker prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT fatimakhalid prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT ibrahimaadam prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT osamahomer prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT mohamedeahmed prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT saralbirair prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT eltahirmharoun prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT hassanabuaisha prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT abdelrahimekarrar prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT hamidsabdalla prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan AT imadeldinearadaib prevalenceofdenguefevervirusantibodiesandassociatedriskfactorsamongresidentsofelgadarifstatesudan |