Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study
BackgroundThe Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) item library covers a wide range of symptoms relevant to oncology care. There is a need to select a subset of items relevant to specific patient populations to en...
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| Format: | Article |
| Language: | English |
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JMIR Publications
2021-09-01
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| Series: | JMIR Cancer |
| Online Access: | https://cancer.jmir.org/2021/3/e26574 |
| _version_ | 1827858997473968128 |
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| author | Evalien Veldhuijzen Iris Walraven José Belderbos |
| author_facet | Evalien Veldhuijzen Iris Walraven José Belderbos |
| author_sort | Evalien Veldhuijzen |
| collection | DOAJ |
| description |
BackgroundThe Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) item library covers a wide range of symptoms relevant to oncology care. There is a need to select a subset of items relevant to specific patient populations to enable the implementation of PRO-CTCAE–based symptom monitoring in clinical practice.
ObjectiveThe aim of this study is to develop a PRO-CTCAE–based subset relevant to patients with lung cancer that can be used for monitoring during multidisciplinary clinical practice.
MethodsThe PRO-CTCAE–based subset for patients with lung cancer was generated using a mixed methods approach based on the European Organization for Research and Treatment of Cancer guidelines for developing questionnaires, comprising a literature review and semistructured interviews with both patients with lung cancer and health care practitioners (HCPs). Both patients and HCPs were queried on the relevance and impact of all PRO-CTCAE items. The results were summarized, and after a final round of expert review, a selection of clinically relevant items for patients with lung cancer was made.
ResultsA heterogeneous group of patients with lung cancer (n=25) from different treatment modalities and HCPs (n=22) participated in the study. A final list of eight relevant PRO-CTCAE items was created: decreased appetite, cough, shortness of breath, fatigue, constipation, nausea, sadness, and pain (general).
ConclusionsOn the basis of the literature and both professional and patient input, a subset of PRO-CTCAE items has been identified for use in patients with lung cancer in clinical practice. Future work is needed to confirm the validity and effectiveness of this PRO-CTCAE–based lung cancer subset internationally and in real-world clinical practice settings. |
| first_indexed | 2024-03-12T13:03:03Z |
| format | Article |
| id | doaj.art-0e62823e3cda4b21ae0b82572a17c798 |
| institution | Directory Open Access Journal |
| issn | 2369-1999 |
| language | English |
| last_indexed | 2024-03-12T13:03:03Z |
| publishDate | 2021-09-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Cancer |
| spelling | doaj.art-0e62823e3cda4b21ae0b82572a17c7982023-08-28T19:03:26ZengJMIR PublicationsJMIR Cancer2369-19992021-09-0173e2657410.2196/26574Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods StudyEvalien Veldhuijzenhttps://orcid.org/0000-0003-3594-3300Iris Walravenhttps://orcid.org/0000-0002-6083-730XJosé Belderboshttps://orcid.org/0000-0002-6434-6436 BackgroundThe Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) item library covers a wide range of symptoms relevant to oncology care. There is a need to select a subset of items relevant to specific patient populations to enable the implementation of PRO-CTCAE–based symptom monitoring in clinical practice. ObjectiveThe aim of this study is to develop a PRO-CTCAE–based subset relevant to patients with lung cancer that can be used for monitoring during multidisciplinary clinical practice. MethodsThe PRO-CTCAE–based subset for patients with lung cancer was generated using a mixed methods approach based on the European Organization for Research and Treatment of Cancer guidelines for developing questionnaires, comprising a literature review and semistructured interviews with both patients with lung cancer and health care practitioners (HCPs). Both patients and HCPs were queried on the relevance and impact of all PRO-CTCAE items. The results were summarized, and after a final round of expert review, a selection of clinically relevant items for patients with lung cancer was made. ResultsA heterogeneous group of patients with lung cancer (n=25) from different treatment modalities and HCPs (n=22) participated in the study. A final list of eight relevant PRO-CTCAE items was created: decreased appetite, cough, shortness of breath, fatigue, constipation, nausea, sadness, and pain (general). ConclusionsOn the basis of the literature and both professional and patient input, a subset of PRO-CTCAE items has been identified for use in patients with lung cancer in clinical practice. Future work is needed to confirm the validity and effectiveness of this PRO-CTCAE–based lung cancer subset internationally and in real-world clinical practice settings.https://cancer.jmir.org/2021/3/e26574 |
| spellingShingle | Evalien Veldhuijzen Iris Walraven José Belderbos Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study JMIR Cancer |
| title | Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study |
| title_full | Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study |
| title_fullStr | Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study |
| title_full_unstemmed | Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study |
| title_short | Selecting a Subset Based on the Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events for Patient-Reported Symptom Monitoring in Lung Cancer Treatment: Mixed Methods Study |
| title_sort | selecting a subset based on the patient reported outcomes version of the common terminology criteria for adverse events for patient reported symptom monitoring in lung cancer treatment mixed methods study |
| url | https://cancer.jmir.org/2021/3/e26574 |
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