The angiotensin-converting enzyme () I/D polymorphism in Parkinson’s disease
Objective: The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson’s disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2015-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313494432 |
| Summary: | Objective: The angiotensin-converting enzyme (ACE) may be involved in the pathogenesis of Parkinson’s disease (PD). There have been several studies investigating the association between ACE gene I/D polymorphism and PD risk, but they reported inconsistent findings. We performed a meta-analysis to investigate the association between ACE gene I/D polymorphism and PD risk. Methods: Published literature from PubMed and Embase databases were searched for eligible publications. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models based on between-study heterogeneity. Results: A total of five studies including 606 cases and 708 controls were finally included in the meta-analysis. Meta-analysis showed that there was no obvious association between ACE gene I/D polymorphism and PD risk under the homogeneous co-dominant model (OR = 1.14, 95% CI = 0.71–1.82), heterogeneous co-dominant model (OR = 0.92, 95% CI = 0.70–1.22), dominant model (OR = 0.99, 95% CI = 0.76–1.28) or recessive model (OR = 1.07, 95% CI = 0.83–1.37). Conclusion: The meta-analysis suggests that there is no evidence for the association between ACE gene I/D polymorphism and PD risk. |
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| ISSN: | 1470-3203 1752-8976 |